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Difference between revisions of "Oncocytoma of the salivary gland"
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Oncocytoma of the salivary gland (view source)
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'''Oncocytoma of the salivary gland''' is a rare benign tumour of the [[salivary glands]]. | |||
==General== | |||
*No risk of malignant transformation. | |||
*Rare ~20 reported in literature.<ref>{{cite journal |author=Uzunkulaoğlu H, Yazici H, Can IH, Doğan S, Uzunkulaoğlu T |title=Bilateral oncocytoma in the parotid gland |journal=J Craniofac Surg |volume=23 |issue=3 |pages=e246–7 |year=2012 |month=May |pmid=22627459 |doi=10.1097/SCS.0b013e31824dfccd |url=}}</ref> | |||
*Thought to be ~1% of all salivary gland tumours. | |||
*Typical age: 60s-80s. | |||
*Associated with radiation exposure. | |||
*Major salivary glands - usually parotid gland.<ref name=pmid19796983>{{Cite journal | last1 = Zhou | first1 = CX. | last2 = Gao | first2 = Y. | title = Oncocytoma of the salivary glands: a clinicopathologic and immunohistochemical study. | journal = Oral Oncol | volume = 45 | issue = 12 | pages = e232-8 | month = Dec | year = 2009 | doi = 10.1016/j.oraloncology.2009.08.004 | PMID = 19796983 }}</ref> | |||
==Gross== | |||
*Golden brown appearance. | |||
===Image=== | |||
<gallery> | |||
Image:Oncocytoma_of_the_Salivary_Gland.jpg | Salivary gland oncocytoma (WC/euthman) | |||
</gallery> | |||
===Microscopic=== | |||
Features: | |||
*Like [[oncocytoma]]s elsewhere. | |||
**Eosinophilic cytoplasm (on [[H&E stain]]). | |||
***Due to increased number of mitochrondria. | |||
**Fine capillaries. | |||
*Architecture: solid sheets, trabeculae or duct-like structure.<ref name=pmid19796983/> | |||
Notes: | |||
*May have clear cell change. | |||
*Multiple small incidental lesions = oncocytosis - ''not'' oncocytoma. | |||
DDx: | |||
*[[Acinic cell carcinoma]]. | |||
===Images=== | |||
www: | |||
*[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2807526/figure/Fig1/ Salivary gland oncocytoma (nih.gov)].<ref name=pmid20614263/> | |||
<gallery> | |||
Image:Parotid_gland_oncocytoma_-_intermed_mag.jpg | Parotid gland oncocytoma - intermed. mag. (WC/Nephron) | |||
Image: Parotid gland oncocytoma - high mag.jpg | Parotid gland oncocytoma - high mag. (WC/Nephron) | |||
Image:Parotid_gland_oncocytoma_-_very_high_mag.jpg | Parotid gland oncocytoma - very high mag. (WC/Nephron) | |||
</gallery> | |||
==IHC== | |||
*p63 +ve<ref name=pmid20614263>{{Cite journal | last1 = McHugh | first1 = JB. | last2 = Hoschar | first2 = AP. | last3 = Dvorakova | first3 = M. | last4 = Parwani | first4 = AV. | last5 = Barnes | first5 = EL. | last6 = Seethala | first6 = RR. | title = p63 immunohistochemistry differentiates salivary gland oncocytoma and oncocytic carcinoma from metastatic renal cell carcinoma. | journal = Head Neck Pathol | volume = 1 | issue = 2 | pages = 123-31 | month = Dec | year = 2007 | doi = 10.1007/s12105-007-0031-4 | PMID = 20614263 | PMC = 2807526}}</ref> focally in nucleus. | |||
==See also== | |||
*[[Oncocytoma]]. | |||
*[[Salivary glands]]. | |||
==References== | |||
{{Reflist|2}} | |||
[[Category:Diagnosis]] | [[Category:Diagnosis]] | ||
[[Category:Salivary gland]] | |||