Difference between revisions of "Course:Introduction to Neuropathology"

Cells and tissues have numerous antigenic structures that serve as a target for the receptors of an adaptive immune response. These structures are found at cell surface, in cytoplasm or organelles (including the nucleus). Several antigens are found only in a specific tissue type (ie. epithelial cells) or at a given stage of the cell cycle (proliferating cells). Because human antigens are of diagnostic and/or prognostic relevance, especially in cancer diagnostics, they are often called biomarkers. Since its introduction in 1974 <ref name="pmid4132252">{{Cite journal  | last1 = Taylor | first1 = CR. | last2 = Burns | first2 = J. | title = The demonstration of plasma cells and other immunoglobulin-containing cells in formalin-fixed, paraffin-embedded tissues using peroxidase-labelled antibody. | journal = J Clin Pathol | volume = 27 | issue = 1 | pages = 14-20 | month = Jan | year = 1974 | doi =  | PMID = 4132252 }}</ref>, the visualization of epitopes in paraffin-embedded specimens through [[immunohistochemistry]] has become standard practice in routine neuropathology supporting the morphology at light-microscope level.  

Cells and tissues have numerous antigenic structures that serve as a target for the receptors of an adaptive immune response. These structures are found at cell surface, in cytoplasm or organelles (including the nucleus). Several antigens are found only in a specific tissue type (ie. epithelial cells) or at a given stage of the cell cycle (proliferating cells). Because human antigens are of diagnostic and/or prognostic relevance, especially in cancer diagnostics, they are often called biomarkers. Since its introduction in 1974 <ref name="pmid4132252">{{Cite journal  | last1 = Taylor | first1 = CR. | last2 = Burns | first2 = J. | title = The demonstration of plasma cells and other immunoglobulin-containing cells in formalin-fixed, paraffin-embedded tissues using peroxidase-labelled antibody. | journal = J Clin Pathol | volume = 27 | issue = 1 | pages = 14-20 | month = Jan | year = 1974 | doi =  | PMID = 4132252 }}</ref>, the visualization of epitopes in paraffin-embedded specimens through [[immunohistochemistry]] has become standard practice in routine neuropathology supporting the morphology at light-microscope level.  

===Day 2===

===Day 2===