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Small vessel leukocytoclastic vasculitis (view source)
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# | '''Small vessel leukocytoclastic vasculitis''', also '''leukocytoclastic vasculitis''' (abbreviated '''LCV'''), is an inflammatory process of the small [[blood vessel]]. | ||
==General== | |||
*Most common cutaneous vasculitis.<ref name=pmid18948765>{{Cite journal | last1 = Brinster | first1 = NK. | title = Dermatopathology for the surgical pathologist: a pattern-based approach to the diagnosis of inflammatory skin disorders (part II). | journal = Adv Anat Pathol | volume = 15 | issue = 6 | pages = 350-69 | month = Nov | year = 2008 | doi = 10.1097/PAP.0b013e31818b1ac6 | PMID = 18948765 }}</ref> | |||
Clinical: | |||
*Palpable purpura, usu. lower extremity. | |||
==Microscopic== | |||
Features:<ref name=pmid18948765/> | |||
*Small upper dermis vessels with: | |||
*#Neutrophils. | |||
*#*Fragmentation of neutrophils (leukocytoclasia). | |||
*#Vessel damage: fibrin deposition (bright pink acellular stuff). | |||
Has a very broad DDx:<ref name=pmid18948765/> | |||
#Infectious: | |||
#*Bacterial. | |||
#*Viral. | |||
#*[[Fungal]]. | |||
#Vasculitic disorders: | |||
#*ANCA mediated vasculitides: | |||
#**[[Wegener granulomatosis]]. | |||
#**[[Churg-Strauss syndrome]]. | |||
#*[[Henoch–Schönlein purpura]].<ref name=pmid9713395>{{Cite journal | last1 = Kraft | first1 = DM. | last2 = Mckee | first2 = D. | last3 = Scott | first3 = C. | title = Henoch-Schönlein purpura: a review. | journal = Am Fam Physician | volume = 58 | issue = 2 | pages = 405-8, 411 | month = Aug | year = 1998 | doi = | PMID = 9713395 }}</ref> | |||
#*Urticarial vasculitis. | |||
#Other: | |||
#*[[Connective tissue disease]], e.g. [[mixed connective tissue disease]], [[SLE]], [[rheumatoid arthritis]]. | |||
#*[[Cryoglobulinemia]] - may be due to [[multiple myeloma]], [[hepatitis C]]; have intravascular thrombi. | |||
#*Paraneoplastic. | |||
#*Drugs. | |||
Image: | |||
*[http://www.ancavasculitis.com/biopsy.php LCA (ancavasculitis.com)]. | |||
*[http://path.upmc.edu/cases/case189.html LCA of the GI tract - several images (upmc.edu)]. | |||
==Stains== | |||
*PAS - look for fungus. | |||
==See also== | |||
*[[Vasculitides]]. | |||
==References== | |||
{{Reflist|2}} | |||
[[Category:Diagnosis]] | [[Category:Diagnosis]] | ||
[[Category:Vasculitides]] | |||