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Difference between revisions of "Adenosis of the prostate gland"
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'''Adenosis of the prostate''', | '''Adenosis of the prostate gland''', also '''adenosis of the prostate''', is a benign change of the prostate gland, typically seen in the transistion zone of the prostate, and may be mistaken for (low grade) [[prostatic adenocarcinoma]].<ref name=pmid7793471>{{Cite journal | last1 = Gaudin | first1 = PB. | last2 = Epstein | first2 = JI. | title = Adenosis of the prostate. Histologic features in needle biopsy specimens. | journal = Am J Surg Pathol | volume = 19 | issue = 7 | pages = 737-47 | month = Jul | year = 1995 | doi = | PMID = 7793471 }}</ref> | ||
It is also known as '''[[atypical adenomatous hyperplasia]]'''.<ref name=pmid22520603>{{Cite journal | last1 = Molinié | first1 = V. | last2 = Vadrot | first2 = J. | last3 = Duchatelle | first3 = V. | last4 = Balaton | first4 = A. | last5 = Abbey-Tobby | first5 = A. | last6 = Baumert | first6 = H. | title = [Diagnostic issues of prostate biopsies. Case 2. Atypical adenomatous hyperplasia (adenosis)]. | journal = Ann Pathol | volume = 32 | issue = 2 | pages = 114-7 | month = Apr | year = 2012 | doi = 10.1016/j.annpat.2012.02.003 | PMID = 22520603 }}</ref><ref name=pmid23000851>{{Cite journal | last1 = Humphrey | first1 = PA. | title = Atypical adenomatous hyperplasia (adenosis) of the prostate. | journal = J Urol | volume = 188 | issue = 6 | pages = 2371-2 | month = Dec | year = 2012 | doi = 10.1016/j.juro.2012.09.058 | PMID = 23000851 }}</ref> | |||
==General== | |||
*May be mistaken for [[prostatic adenocarcinoma]].<ref name=pmid22212076>{{Cite journal | last1 = Epstein | first1 = JI. | title = Diagnosis of limited adenocarcinoma of the prostate. | journal = Histopathology | volume = 60 | issue = 1 | pages = 28-40 | month = Jan | year = 2012 | doi = 10.1111/j.1365-2559.2011.03990.x | PMID = 22212076 }}</ref> | |||
*Lesion of the transistion zone of the prostate.<ref name=pmid7793471>{{Cite journal | last1 = Gaudin | first1 = PB. | last2 = Epstein | first2 = JI. | title = Adenosis of the prostate. Histologic features in needle biopsy specimens. | journal = Am J Surg Pathol | volume = 19 | issue = 7 | pages = 737-47 | month = Jul | year = 1995 | doi = | PMID = 7793471 }}</ref> | |||
==Microscopic== | |||
Features: | |||
*Glandular crowding. | |||
**Glands may be back-to-back. | |||
*Lack of prominent [[nucleoli]]. | |||
DDx: | |||
*[[Adenocarcinoma of the prostate]] - esp. [[foamy gland adenocarcinoma]]. | |||
==IHC== | |||
*CK5/6 +ve. ‡ | |||
*p63 +ve. ‡ | |||
*AMACR -ve. | |||
Notes: | |||
*‡ Often patchy - some glands in a group may lack basal cells. | |||
==See also== | ==See also== | ||
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==References== | ==References== | ||
{{Reflist| | {{Reflist|2}} | ||
[[Category:Prostate gland]] | [[Category:Prostate gland]] | ||