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Difference between revisions of "Post-infectious glomerulonephritis"
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Post-infectious glomerulonephritis (view source)
Revision as of 06:24, 11 April 2015
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{{ Infobox diagnosis | |||
| Name = {{PAGENAME}} | |||
| Image = Post-infectious_glomerulonephritis_-_very_high_mag.jpg | |||
| Width = | |||
| Caption = Post-infectious glomerulonephritis. [[H&E stain]]. | |||
| Synonyms = | |||
| Micro = +/-neutrophils in glomerulus, [[glomerular crescents]] | |||
| Subtypes = | |||
| LMDDx = | |||
| Stains = | |||
| IHC = | |||
| EM = subepithelial deposits, hump-like | |||
| Molecular = | |||
| IF = granular immune deposits | |||
| Gross = | |||
| Grossing = | |||
| Site = [[kidney]] - see ''[[medical kidney diseases]]'' | |||
| Assdx = post-infection, e.g. [[pneumonia]] | |||
| Syndromes = | |||
| Clinicalhx = | |||
| Signs = [[nephritic syndrome]] (proteinuria, [[hypertension]], azotemia, [[RBC]] casts, oliguria, hematuria) | |||
| Symptoms = | |||
| Prevalence = uncommon | |||
| Bloodwork = | |||
| Rads = | |||
| Endoscopy = | |||
| Prognosis = usually good | |||
| Other = | |||
| ClinDDx = | |||
| Tx = | |||
}} | |||
'''Post-infectious glomerulonephritis''', abbreviated '''PIGN''', is a rarely biopsied glomerulonephritis classically associated with a streptococcal infection. | '''Post-infectious glomerulonephritis''', abbreviated '''PIGN''', is a rarely biopsied glomerulonephritis classically associated with a streptococcal infection. | ||
==General== | ==General== | ||
*Classically post-streptococcal infection. | *Classically post-streptococcal infection.<ref name=pmid12746805>{{Cite journal | last1 = Barbiano Di Belgiojoso | first1 = G. | last2 = Genderini | first2 = A. | last3 = Ferrario | first3 = F. | title = [Post-infectious glomerulonephritis]. | journal = G Ital Nefrol | volume = 20 | issue = 2 | pages = 184-99 | month = | year = | doi = | PMID = 12746805 }}</ref><ref name=pmid24777751/> | ||
**Lab test: Antistreptolysin O titer (ASOT) +ve. | **Lab test: Antistreptolysin O titer (ASOT) +ve. | ||
Clinical: | |||
*[[Nephritic syndrome]].<ref name=pmid24777751>{{Cite journal | last1 = Stratta | first1 = P. | last2 = Musetti | first2 = C. | last3 = Barreca | first3 = A. | last4 = Mazzucco | first4 = G. | title = New trends of an old disease: the acute post infectious glomerulonephritis at the beginning of the new millenium. | journal = J Nephrol | volume = 27 | issue = 3 | pages = 229-39 | month = Jun | year = 2014 | doi = 10.1007/s40620-013-0018-z | PMID = 24777751 }}</ref> | |||
==Microscopic== | ==Microscopic== | ||
| Line 23: | Line 57: | ||
==EM== | ==EM== | ||
*Subepithelial deposits - hump-like. | *Subepithelial deposits - hump-like.<ref name=pmid18162726>{{Cite journal | last1 = Sung | first1 = HY. | last2 = Lim | first2 = CH. | last3 = Shin | first3 = MJ. | last4 = Kim | first4 = BS. | last5 = Kim | first5 = YO. | last6 = Song | first6 = HC. | last7 = Kim | first7 = SY. | last8 = Choi | first8 = EJ. | last9 = Chang | first9 = YS. | title = A case of post-streptococcal glomerulonephritis with diffuse alveolar hemorrhage. | journal = J Korean Med Sci | volume = 22 | issue = 6 | pages = 1074-8 | month = Dec | year = 2007 | doi = | PMID = 18162726 }}</ref> | ||
**Larger when measured perpendicular to the basement membrane, if compared to [[membranous nephropathy]]. | **Larger when measured perpendicular to the basement membrane, if compared to [[membranous nephropathy]]. | ||
**Typically focal. | **Typically focal. | ||