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Difference between revisions of "Thyroid gland"
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→Benign: C cell hyperplasia
(→Benign: C cell hyperplasia) |
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Notes: | Notes: | ||
*Histologically often not possible to separate from "nonspecific" thyroiditis.<ref name=Ref_Sternberg4_560>{{Ref Sternberg4|560}}</ref> | *Histologically often not possible to separate from "nonspecific" thyroiditis.<ref name=Ref_Sternberg4_560>{{Ref Sternberg4|560}}</ref> | ||
==C cell hyperplasia== | |||
===General=== | |||
*Screening for C cell hyperplasia/medullary thyroid carcinoma done with ''serum calcitonin level''.<ref name=pmid19726541>{{cite journal |author=Machens A, Hoffmann F, Sekulla C, Dralle H |title=Importance of gender-specific calcitonin thresholds in screening for occult sporadic medullary thyroid cancer |journal=Endocr. Relat. Cancer |volume=16 |issue=4 |pages=1291–8 |year=2009 |month=December |pmid=19726541 |doi=10.1677/ERC-09-0136 |url=http://erc.endocrinology-journals.org/cgi/content/full/16/4/1291}}</ref> | |||
===Microscopic=== | |||
Features: | |||
*Definitions vary.<ref>SR. 17 January 2011.</ref> | |||
One definition - either of the following:<ref name=pmid19726541>{{cite journal |author=Machens A, Hoffmann F, Sekulla C, Dralle H |title=Importance of gender-specific calcitonin thresholds in screening for occult sporadic medullary thyroid cancer |journal=Endocr. Relat. Cancer |volume=16 |issue=4 |pages=1291–8 |year=2009 |month=December |pmid=19726541 |doi=10.1677/ERC-09-0136 |url=http://erc.endocrinology-journals.org/cgi/content/full/16/4/1291}}</ref> | |||
#>50 C-cells per low-power field (x100); this suffers from [[LFPitis]]. | |||
#Confined to the thyroid gland and no larger than 10 mm in greatest dimension. | |||
Another definition: | |||
*Invasion of the basement membrane with stromal reaction. | |||
A third definition: | |||
*"Several clusters of more than six C cells. | |||
=Malignant neoplasm= | =Malignant neoplasm= | ||