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Difference between revisions of "Myoepithelioma"
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'''Myoepithelioma''' is a benign tumour of the [[head and neck pathology|head and neck]]. | |||
==General== | |||
*Usually benign. | |||
**May be malignant. | |||
Location - head and neck:<ref name=pmid2982059>{{Cite journal | last1 = Barnes | first1 = L. | last2 = Appel | first2 = BN. | last3 = Perez | first3 = H. | last4 = El-Attar | first4 = AM. | title = Myoepithelioma of the head and neck: case report and review. | journal = J Surg Oncol | volume = 28 | issue = 1 | pages = 21-8 | month = Jan | year = 1985 | doi = | PMID = 2982059 }}</ref> | |||
*Parotid gland ~50%. | |||
*Palate ~25% | |||
*Submandibular gland ~12%. | |||
Notes: | |||
*First described in 1972.<ref name=pmid5075358>{{Cite journal | last1 = Saksela | first1 = E. | last2 = Tarkkanen | first2 = J. | last3 = Wartiovaara | first3 = J. | title = Parotid clear-cell adenoma of possible myoepithelial origin. | journal = Cancer | volume = 30 | issue = 3 | pages = 742-8 | month = Sep | year = 1972 | doi = | PMID = 5075358 }}</ref> | |||
*May be seen in the skin.<ref name=pmid11224605>{{Cite journal | last1 = Kutzner | first1 = H. | last2 = Mentzel | first2 = T. | last3 = Kaddu | first3 = S. | last4 = Soares | first4 = LM. | last5 = Sangueza | first5 = OP. | last6 = Requena | first6 = L. | title = Cutaneous myoepithelioma: an under-recognized cutaneous neoplasm composed of myoepithelial cells. | journal = Am J Surg Pathol | volume = 25 | issue = 3 | pages = 348-55 | month = Mar | year = 2001 | doi = | PMID = 11224605 }}</ref> | |||
==Microsopic== | |||
Features:<ref name=Ref_DCHH130>{{Ref DCHH|130}}</ref> | |||
*Myoepithelial cells - may be: | |||
**Spindled. | |||
**Plasmacytoid. | |||
**Epithelioid. | |||
**Clear (rare). | |||
*Lack tubules, i.e. epithelial component. | |||
**May be up to 10% (or 5%<ref>I. Weinreb. 24 October 2011.</ref>). | |||
DDx: | |||
*[[Pleomorphic adenoma]]. | |||
===Images=== | |||
<gallery> | |||
Image: Myoepithelioma - low mag.jpg | Myoepithelioma - low mag. (WC/Nephron) | |||
Image: Myoepithelioma_-_intermed_mag.jpg | Myoepithelioma - intermed. mag. (WC/Nephron) | |||
Image: Myoepithelioma - high mag.jpg | Myoepithelioma - high mag. (WC/Nephron) | |||
Image: Myoepithelioma_-_very_high_mag.jpg | Myoepithelioma - very high mag. (WC/Nephron) | |||
</gallery> | |||
==IHC== | |||
Features:<ref name=Ref_DCHH130>{{Ref DCHH|130}}</ref> | |||
*S100 +ve. | |||
*GFAP +ve. | |||
*CK14 +ve. | |||
Others:<ref name=Ref_DCHH18>{{Ref DCHH|18}}</ref> | |||
*SMA +ve. | |||
*Calponin +ve. | |||
==See also== | |||
*[[Salivary gland]]. | |||
==References== | |||
{{Reflist|2}} | |||
[[Category:Diagnosis]] | [[Category:Diagnosis]] | ||
[[Category:Salivary gland]] | |||