Difference between revisions of "Neurodegenerative diseases"

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Neurodegenerative diseases (view source)

Revision as of 21:47, 16 February 2015

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→‎Chronic traumatic encephalopathy: split out
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==Chronic traumatic encephalopathy==
==Chronic traumatic encephalopathy==
*Abbreviated ''CTE''.
*Abbreviated ''CTE''.
===General===
{{Main|Chronic traumatic encephalopathy}}
*Due to head trauma - usually repetitive.
**Seen in ''American football'' and ''boxing''.
***The in the context of boxing it is known as ''dementia pugilistica''; ''pugil'' is ''boxer'' in Latin.<ref>URL: [http://dictionary.reference.com/browse/pugilism http://dictionary.reference.com/browse/pugilism]. Accessed on: 21 November 2011.</ref>
*May be associated with motor neuron disease.<ref name=pmid22050943>{{Cite journal  | last1 = Daneshvar | first1 = DH. | last2 = Riley | first2 = DO. | last3 = Nowinski | first3 = CJ. | last4 = McKee | first4 = AC. | last5 = Stern | first5 = RA. | last6 = Cantu | first6 = RC. | title = Long-term consequences: effects on normal development profile after concussion. | journal = Phys Med Rehabil Clin N Am | volume = 22 | issue = 4 | pages = 683-700 | month = Nov | year = 2011 | doi = 10.1016/j.pmr.2011.08.009 | PMID = 22050943 }}</ref>
 
===Microscopic===
Features:<ref name=pmid22035690>{{Cite journal  | last1 = Stern | first1 = RA. | last2 = Riley | first2 = DO. | last3 = Daneshvar | first3 = DH. | last4 = Nowinski | first4 = CJ. | last5 = Cantu | first5 = RC. | last6 = McKee | first6 = AC. | title = Long-term Consequences of Repetitive Brain Trauma: Chronic Traumatic Encephalopathy. | journal = PM R | volume = 3 | issue = 10 Suppl 2 | pages = S460-7 | month = Oct | year = 2011 | doi = 10.1016/j.pmrj.2011.08.008 | PMID = 22035690 }}</ref>
*Wall-to-wall neurofibrillary tangles.
**Common in olfactory bulb, mammillary bodies, hippocampus.
**Usually perivascular.
**Often superficial (unlike [[Alzheimer disease]]) and at the deep aspect of sulci.
 
===IHC===
*Increased TDP-43 staining.
 
Note:
*[[ALS]] associated with trauma brain injuries.<ref name=pmid21696410>{{Cite journal  | last1 = Costanza | first1 = A. | last2 = Weber | first2 = K. | last3 = Gandy | first3 = S. | last4 = Bouras | first4 = C. | last5 = Hof | first5 = PR. | last6 = Giannakopoulos | first6 = P. | last7 = Canuto | first7 = A. | title = Review: Contact sport-related chronic traumatic encephalopathy in the elderly: clinical expression and structural substrates. | journal = Neuropathol Appl Neurobiol | volume = 37 | issue = 6 | pages = 570-84 | month = Oct | year = 2011 | doi = 10.1111/j.1365-2990.2011.01186.x | PMID = 21696410 }}</ref>


==Huntington disease==
==Huntington disease==
Michael
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