653
edits
Difference between revisions of "Chondrosarcoma"
Jump to navigation
Jump to search
→Variants
| Line 126: | Line 126: | ||
*Pathology outlines [http://pathologyoutlines.com/wick/softtissue/chondrosarcomaextraskeletalmyxoidtypemicro1.jpg] | *Pathology outlines [http://pathologyoutlines.com/wick/softtissue/chondrosarcomaextraskeletalmyxoidtypemicro1.jpg] | ||
*Pathology outlines [http://pathologyoutlines.com/wick/softtissue/chondrosarcomaextraskeletalmyxoidtypemicro2.jpg] | *Pathology outlines [http://pathologyoutlines.com/wick/softtissue/chondrosarcomaextraskeletalmyxoidtypemicro2.jpg] | ||
====Clear cell chondrosarcoma==== | |||
*Rare variant of chondrosarcoma (1.6%–5.4% of all chondrosarcomas) | |||
*Low-grade malignant tumour | |||
*Younger age than conventional chondrosarcoma | |||
*Ages 15-25 years, more common in males | |||
*Epiphyses of long tubular bones; proximal femur or humerus | |||
*May represent malignant counterpart of chondroblastoma <ref>{{Cite journal | last1 = Corradi | first1 = D. | last2 = Bacchini | first2 = P. | last3 = Campanini | first3 = N. | last4 = Bertoni | first4 = F. | title = Aggressive clear cell chondrosarcomas: do distinctive characteristics exist?: a report of 4 cases. | journal = Arch Pathol Lab Med | volume = 130 | issue = 11 | pages = 1673-9 | month = Nov | year = 2006 | doi = 10.1043/1543-2165(2006)130[1673:ACCCDD]2.0.CO;2 | PMID = 17076530 }}</ref> | |||
Microscopic findings | |||
*Lobules of tumor cells with sharply defined borders | |||
*Clear or ground-glass cytoplasm with vacuoles | |||
*Central nuclei with occasional prominent nucleoli | |||
*Numerous osteoclast-type giant cells mixed with small trabeculae of reactive bone | |||
*50% also contain conventional low-grade chondrosarcoma | |||
May have secondary aneurysmal bone cyst changes | |||
<gallery> | |||
Image:Bone Chondrosarcoma ClearCell HP PA.jpg|High grade round cells with cytoplasmic clearing. (SKB) | |||
Image:Bone Chondrosarcoma ClearCell MP3 PA.jpg|High grade round cells with cytoplasmic clearing. (SKB) | |||
Image:Bone Chondrosarcoma ClearCell MP4 PA.jpg|thumb|Clear cells, giant cells and bone spicules. (SKB) | |||
Image:Bone Chondrosarcoma ClearCell MP2 PA.jpg|thumb|Somewhat hemangiopericytomatous vascular pattern with giant cells. (SKB) | |||
Image:Bone Chondrosarcoma ClearCell MP4 PA.jpg|thumb|Clear cells, giant cells and bone spicules. (SKB) | |||
Image:Bone Chondrosarcoma ClearCell MP PA.jpg|thumb|The lesion also had areas of more conventional chondrosarcoma. (SKB) | |||
</gallery> | |||
*Pathology outlines [http://pathologyoutlines.com/wick/chondrosarcoma%20clear%20cell%20type%20micro7.jpg] | |||
*Pathology outlines [http://pathologyoutlines.com/wick/chondrosarcoma%20clear%20cell%20type%20micro8.jpg] | |||
*Pathology outlines [http://pathologyoutlines.com/wick/chondrosarcoma%20clear%20cell%20type%20micro2.jpg] | |||
DDX: | |||
*Chondroblastoma | |||
====Extraskeletal myxoid chondrosarcoma==== | ====Extraskeletal myxoid chondrosarcoma==== | ||