48,830
edits
(→IHC) |
|||
Line 12: | Line 12: | ||
==Microscopic== | ==Microscopic== | ||
Features:<ref name=pmid22885379/> | Features:<ref name=pmid22885379/> | ||
*Clear cytoplasm - '''key feature'''. | |||
**May be focal/absent! | |||
**Cells have large free/luminal surface area (hobnailing pattern) and small non-free surface. | **Cells have large free/luminal surface area (hobnailing pattern) and small non-free surface. | ||
*Moderate-to-severe [[nuclear pleomorphism]]. | |||
*Tubular and/or cystic morphology. | |||
**May be (simple) papillary and/or solid. | |||
*Adenosis - typically adjacent. | *Adenosis - typically adjacent. | ||
Line 24: | Line 23: | ||
*[[Clear cell carcinoma of the endometrium]] - diagnosis based on clinico-radiologic correlation (IHC & histology not useful).<ref name=pmid22885379>{{Cite journal | last1 = Offman | first1 = SL. | last2 = Longacre | first2 = TA. | title = Clear cell carcinoma of the female genital tract (not everything is as clear as it seems). | journal = Adv Anat Pathol | volume = 19 | issue = 5 | pages = 296-312 | month = Sep | year = 2012 | doi = 10.1097/PAP.0b013e31826663b1 | PMID = 22885379 }}</ref> | *[[Clear cell carcinoma of the endometrium]] - diagnosis based on clinico-radiologic correlation (IHC & histology not useful).<ref name=pmid22885379>{{Cite journal | last1 = Offman | first1 = SL. | last2 = Longacre | first2 = TA. | title = Clear cell carcinoma of the female genital tract (not everything is as clear as it seems). | journal = Adv Anat Pathol | volume = 19 | issue = 5 | pages = 296-312 | month = Sep | year = 2012 | doi = 10.1097/PAP.0b013e31826663b1 | PMID = 22885379 }}</ref> | ||
*[[Serous carcinoma of the endometrium]]. | *[[Serous carcinoma of the endometrium]]. | ||
*[[Serous carcinoma of the uterine cervix | *[[Serous carcinoma]] of the uterine cervix. | ||
*[[Mesonephric adenocarcinoma]]. | *[[Mesonephric adenocarcinoma]]. | ||
edits