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Sinonasal undifferentiated carcinoma (view source)
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'''Sinonasal undifferentiated carcinoma''', abbreviated '''SNUC''', is a rare epithelial malignancy of the [[head and neck pathology|head and neck]]. | |||
==General== | |||
*Aggressive/poor prognosis. | |||
**In the past, survival was measured in months.<ref name=pmid17170968>{{Cite journal | last1 = Pitman | first1 = KT. | last2 = Costantino | first2 = PD. | last3 = Lassen | first3 = LF. | title = Sinonasal undifferentiated carcinoma: current trends in treatment. | journal = Skull Base Surg | volume = 5 | issue = 4 | pages = 269-72 | month = | year = 1995 | doi = | PMID = 17170968 | PMC = 1656535 | url = http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1656535/ }}</ref> | |||
**With (aggressive) combined modality treatment, the overall five-year survival is approximately 75%.<ref name=pmid22476411>{{Cite journal | last1 = Al-Mamgani | first1 = A. | last2 = van Rooij | first2 = P. | last3 = Mehilal | first3 = R. | last4 = Tans | first4 = L. | last5 = Levendag | first5 = PC. | title = Combined-modality treatment improved outcome in sinonasal undifferentiated carcinoma: single-institutional experience of 21 patients and review of the literature. | journal = Eur Arch Otorhinolaryngol | volume = | issue = | pages = | month = Apr | year = 2012 | doi = 10.1007/s00405-012-2008-5 | PMID = 22476411 }}</ref> | |||
==Microscopic== | |||
Features:<ref name=Ref_WMSP38>{{Ref WMSP|38}}</ref> | |||
*Architecture: nested, trabecular or lobular. | |||
*Distinct cellular borders. | |||
*Small-to-moderate cytoplasm. | |||
*+/-Distinct nucleoli. | |||
*Tumour cell size variable (small to large). | |||
Note: | |||
*Glandular and squamous differentiation are absent by definition.<ref name=pmid11904342/> | |||
Images: | |||
*www: | |||
**[http://www.nature.com/modpathol/journal/v15/n3/fig_tab/3880522f7.html SNUC (nature.com)].<ref name=pmid11904342>{{Cite journal | last1 = Mills | first1 = SE. | title = Neuroectodermal neoplasms of the head and neck with emphasis on neuroendocrine carcinomas. | journal = Mod Pathol | volume = 15 | issue = 3 | pages = 264-78 | month = Mar | year = 2002 | doi = 10.1038/modpathol.3880522 | PMID = 11904342 | URL = http://dx.doi.org/10.1038/modpathol.3880522 }}</ref> | |||
**[http://www.pathologypics.com/PictView.aspx?ID=244 SNUC (pathologypics.com)]. | |||
**[http://www.pathologypics.com/PictView.aspx?ID=249 SNUC (pathologypics.com)]. | |||
*[[WC]]: | |||
**[http://commons.wikimedia.org/wiki/File:Sinonasal_undifferentiated_carcinoma_-_low_mag.jpg SNUC - low mag. (WC)]. | |||
**[http://commons.wikimedia.org/wiki/File:Sinonasal_undifferentiated_carcinoma_-_high_mag.jpg SNUC - high mag. (WC)]. | |||
**[http://commons.wikimedia.org/wiki/File:Sinonasal_undifferentiated_carcinoma_-_very_high_mag.jpg SNUC - very high mag. (WC)]. | |||
==IHC== | |||
Features:<ref name=Ref_WMSP38>{{Ref WMSP|38}}</ref> | |||
*Pankeratin +ve. | |||
*[[EMA]] +ve. | |||
*CK7 +ve. | |||
*CK5/6 -ve. | |||
Others: | |||
*NSE +ve/-ve. | |||
*Chromogranin A -ve. | |||
*Synaptophysin -ve. | |||
*p63 +ve/-ve.<ref name=pmid21805120>{{Cite journal | last1 = Wadsworth | first1 = B. | last2 = Bumpous | first2 = JM. | last3 = Martin | first3 = AW. | last4 = Nowacki | first4 = MR. | last5 = Jenson | first5 = AB. | last6 = Farghaly | first6 = H. | title = Expression of p16 in sinonasal undifferentiated carcinoma (SNUC) without associated human papillomavirus (HPV). | journal = Head Neck Pathol | volume = 5 | issue = 4 | pages = 349-54 | month = Dec | year = 2011 | doi = 10.1007/s12105-011-0285-8 | PMID = 21805120 | PMC = 3210220 | URL = http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3210220/ }}</ref> | |||
==See also== | |||
*[[Head and neck pathology]]. | |||
*[[Squamous cell carcinoma of the head and neck]]. | |||
==References== | |||
{{Reflist|2}} | |||
[[Category:Head and neck pathology]] | |||
[[Category:Diagnosis]] | [[Category:Diagnosis]] | ||