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Adenocarcinoma of the uterine cervix (view source)
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'''Adenocarcinoma of the uterine cervix''' is a relative uncommon form of cervical [[cancer]]. Like the more common [[squamous cell carcinoma of the cervix]], it is associated strongly with the [[human papilloma virus]]. | |||
It is also known as '''endocervical adenocarcinoma''' and '''cervical adenocarcinoma'''. | |||
==General== | |||
*Adenocarcinoma of the cervix is much less common than squamous dysplasia of the cervix/SCC of the cervix. | |||
*Arises from the endocervical glands. | |||
==Microscopic== | |||
Features: | |||
*Stromal changes - "[[desmoplastic stroma]]/[[desmoplastic reaction]]". | |||
**Fibrosis/streaming cells. | |||
*Gland fusion. | |||
*Glands too deep -- very fuzzy criterion. | |||
Notes: | |||
*AIS changes - similar to [[colon|colonic]] dysplasia. | |||
*AIS may occur together with CIN. | |||
**Not infrequently they (AIS, CIN) occur together - both are due, indirectly, to HPV infection. | |||
*May be difficult to be certain of invasion. | |||
**A feature suggestive of invasion is ''cytoplasmic eosinophilia''. | |||
DDx: | |||
*[[Microglandular hyperplasia]] - [[NC ratio]] normal, no nuclear atypia. | |||
*[[Endocervical adenocarcinoma in situ]]. | |||
*[[Villoglandular adenocarcinoma]]. | |||
*[[Glassy cell carcinoma]]. | |||
*Metastatic adenocarcinoma. | |||
**[[Endometrioid endometrial carcinoma]]. | |||
**[[Serous endometrial carcinoma]]. | |||
===Images=== | |||
<gallery> | |||
Image:Cervical_adenocarcinoma_-_low_mag.jpg | Cervical adenocarcinoma - low mag. (WC) | |||
Image:Cervical_adenocarcinoma_-_intermed_mag.jpg | Cervical adenocarcinoma - intermed. mag. (WC) | |||
Image:Cervical_adenocarcinoma_-_high_mag.jpg | Cervical adenocarcinoma - high mag. (WC) | |||
</gallery> | |||
==IHC== | |||
Features for diagnosis: | |||
*p16 +ve. | |||
*Ki-67 -- high. | |||
Uterus vs. cervix:<ref>LAE. 15 January 2009.</ref> | |||
*Cervix (typically): CEA +ve, p16 +ve. | |||
**ER -ve, PR -ve, vimentin -ve. | |||
*Uterus (typically): vimentin +ve, ER +ve, PR +ve. | |||
**CEA -ve, p16 -ve. | |||
==See also== | |||
*[[Uterine cervix]]. | |||
*[[Gynecologic cytopathology]]. | |||
==References== | |||
{{Reflist|2}} | |||
[[Category:Diagnosis]] | [[Category:Diagnosis]] | ||
[[Category:Uterine cervix]] | |||