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Solitary fibrous tumour of the pleura (view source)
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'''Solitary fibrous tumour of the pleura''', also '''pleural solitary fibrous tumour''', is a relatively common chest wall tumour. | |||
The solitary fibrous tumour in general is dealt with in the ''[[solitary fibrous tumour]]'' article. | |||
==General== | |||
*Uncommon overall.<ref name=pmid24326857/> | |||
**Common for the anatomical site. | |||
*Benign. | |||
*Slow growing.<ref name=pmid24326857>{{Cite journal | last1 = Mordenti | first1 = P. | last2 = Di Cicilia | first2 = R. | last3 = Delfanti | first3 = R. | last4 = Capelli | first4 = P. | last5 = Paties | first5 = C. | last6 = Cavanna | first6 = L. | title = Solitary fibrous tumors of the pleura: a case report and review of the literature. | journal = Tumori | volume = 99 | issue = 4 | pages = e177-83 | month = | year = | doi = 10.1700/1361.15120 | PMID = 24326857 }}</ref> | |||
*Elderly. | |||
*May be large - impair respiratory function.<ref name=pmid24088920>{{Cite journal | last1 = Abe | first1 = M. | last2 = Nomori | first2 = H. | last3 = Fukazawa | first3 = M. | last4 = Sugimura | first4 = H. | last5 = Narita | first5 = M. | last6 = Takeshi | first6 = A. | title = Giant Solitary Fibrous Tumor of the Pleura Causing Respiratory Insufficiency: Report of 3 Cases. | journal = Ann Thorac Cardiovasc Surg | volume = | issue = | pages = | month = Oct | year = 2013 | doi = | PMID = 24088920 }}</ref> | |||
==Gross/radiology== | |||
*Chest wall. | |||
==Microscopic== | |||
Features: | |||
*Spindle cells - usually bland cytology. | |||
*Patternless pattern. | |||
*+/-Ropy collagen. | |||
Suggestive of malignant:<ref name=pmid24088920/> | |||
*Mitotic rate >4/10 HPF. | |||
**Definition suffers from [[HPFitis]]. | |||
DDx: | |||
*[[Malignant mesothelioma]]. | |||
*Metastatic carcinoma. | |||
*[[Lung adenocarcinoma]]. | |||
===Images=== | |||
<gallery> | |||
Image:Pleural solitary fibrous tumor (1).jpg | Pleural SFT. (WC) | |||
Image:Pleural solitary fibrous tumor (2).jpg | Pleural SFT. (WC) | |||
Image:Pleural solitary fibrous tumor (3).jpg | Pleural SFT. (WC) | |||
</gallery> | |||
www: | |||
*[http://path.upmc.edu/cases/case216/dx.html SFT (upmc.edu)]. | |||
==IHC== | |||
Features: | |||
*CD34 +ve (19/23 cases<ref name=pmid15460417>{{Cite journal | last1 = Chen | first1 = HJ. | last2 = Zhang | first2 = HY. | last3 = Li | first3 = X. | last4 = Guo | first4 = LX. | last5 = Wei | first5 = B. | last6 = Guo | first6 = H. | last7 = Bu | first7 = H. | last8 = Yang | first8 = K. | last9 = Liu | first9 = BL. | title = [Solitary fibrous tumor: the clinicopathologic and immunohistochemical characteristics of 26 cases]. | journal = Sichuan Da Xue Xue Bao Yi Xue Ban | volume = 35 | issue = 5 | pages = 675-9 | month = Sep | year = 2004 | doi = | PMID = 15460417 }}</ref>). | |||
*Ki-67 low (<5%).<ref name=pmid24088920/> | |||
*Vimentin +ve (23/23 cases<ref name=pmid15460417/>). | |||
*BCL2 +ve (23/23 cases<ref name=pmid15460417/>). | |||
*CD99 +ve (23/23 cases<ref name=pmid15460417/>). | |||
*SMA -ve/+ve (7 +ve/23 cases<ref name=pmid15460417/>). | |||
Suggested stains:{{fact}} | |||
*CD34, CD99, BCL2, S-100, Ki-67. | |||
==Sign out== | |||
<pre> | |||
LEFT LUNG ("LARGE PLEURAL BASED MASS"), BIOPSY: | |||
- SOLITARY FIBROUS TUMOUR. | |||
</pre> | |||
===Micro=== | |||
The sections show cellular fibrous tissue with a patternless pattern. No mitotic activity is readily apparent. No significant nuclear atypia is identified. No necrosis is apparent. | |||
==See also== | |||
*[[Solitary fibrous tumour]]. | |||
==References== | |||
{{Reflist|2}} | |||
[[Category:Diagnosis]] | |||
[[Category:Lung tumours]] | |||