48,830
edits
Difference between revisions of "Neuropathology tumours"
Jump to navigation
Jump to search
Neuropathology tumours (view source)
Revision as of 03:36, 23 November 2010
, 03:36, 23 November 2010→Pilocytic astrocytoma: +AT/RT
(→Medulloblastoma: subtypes) |
(→Pilocytic astrocytoma: +AT/RT) |
||
| Line 112: | Line 112: | ||
===Gross=== | ===Gross=== | ||
*Do | *Do '''not''' smear. | ||
===Microscopic=== | ===Microscopic=== | ||
Features: | Features: | ||
*Rosenthal fibres - '''key feature'''. | *Rosenthal fibres - '''key feature'''. | ||
*Eosinophilic granular bodies. | |||
*Low cellularity - when compared to medulloblastoma and ependymoma. | |||
Images: | Images: | ||
| Line 127: | Line 129: | ||
*Ganglioma. | *Ganglioma. | ||
*Alexander's disease (rare leukodystrophy). | *Alexander's disease (rare leukodystrophy). | ||
==Atypical teratoid/rhabdoid tumour== | |||
===General=== | |||
*Usually supratentorial, occasionally in posterior fossa, case reports of spinal cord. | |||
===Microscopic=== | |||
Features: | |||
*Cellular. | |||
*Rhaboid cells. (???) | |||
*Cytoplasm: moderate amount of eosinophilic granular. | |||
*Prominent nucleolus. | |||
*Mitoses. | |||
DDx: | |||
*Primitive neuroectodermal tumour (PNET). | |||
*Diffuse astrocytoma. | |||
*Choroid plexus carcinoma. | |||
*Embryonal carcinoma. | |||
===IHC=== | |||
*BAF-47 -ve ([[AKA]] ''ANI1'') - virtually diagnostic. | |||
**Endothelial cells +ve control. | |||
*S-100 +ve. | |||
**Few other brain tumours express it. | |||
*Vimentin +ve (perinuclear condensation). | |||
Others: | |||
*GFAP +ve (focal - in tumour cells). | |||
*EMA +ve (patchy cytoplasmic). | |||
*Smooth muscle actin +ve. | |||
==Oligodendroglioma== | ==Oligodendroglioma== | ||