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Difference between revisions of "Sjögren syndrome"
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==Microscopic== | ==Microscopic== | ||
Features ([[salivary gland]]):<ref name=pmid19323360/> | Features ([[salivary gland]]):<ref name=pmid19323360/> | ||
* | *"Significant lymphocytic infiltrate" adjacent to viable [[salivary gland]] (or [[lacrimal gland]]) acini - '''key feature'''. | ||
**"Significant" lymphocytic infiltrate: cluster of >= 50 lymphocytes - '''important'''. | **"Significant" lymphocytic infiltrate": cluster of >= 50 lymphocytes - '''important'''. | ||
***Lymphocytes | ***Lymphocytes may be perivascular or periductular.<ref name=pmid12022353/><ref name=pmid8003059/> | ||
***[[Plasma cell]]s should not exceed 10% of the inflammatory infiltrate.<ref name=pmid12022353/> | ***[[Plasma cell]]s should not exceed 10% of the inflammatory infiltrate.<ref name=pmid12022353/> | ||
***May have "benign lymphoepithelial lesions"<ref name=pmid15956090/> - intraepithelial lymphocytes. | ***May have "benign lymphoepithelial lesions"<ref name=pmid15956090/> - intraepithelial lymphocytes. | ||
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DDx: | DDx: | ||
*[[MALT lymphoma]]. | *[[MALT lymphoma]]. | ||
*[[Chronic sialadenitis]]. | *[[Chronic sialadenitis]] - mixed inflammatory infiltrate. | ||
Note: | Note: | ||
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===Focus score=== | ===Focus score=== | ||
*This is a count of significant lymphocytic foci. | Features:<ref name=pmid12022353/> | ||
*This is nothing more than a count of significant lymphocytic foci. | |||
**Significant: >= 50 lymphocytes, adjacent to salivary gland acini. | |||
**One or more is considered significant.<ref name=pmid12006334/> | |||
====Grading - historical==== | ====Grading - historical==== | ||