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Difference between revisions of "Sjögren syndrome"
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*Anti-SSA (Ro) +ve. | *Anti-SSA (Ro) +ve. | ||
*Anti-SSB (La) +ve. | *Anti-SSB (La) +ve. | ||
===Diagnostic criteria=== | |||
Four of six criteria required, must include either autoantibodies or histology:<ref>{{Cite journal | last1 = Vivino | first1 = FB. | last2 = Gala | first2 = I. | last3 = Hermann | first3 = GA. | title = Change in final diagnosis on second evaluation of labial minor salivary gland biopsies. | journal = J Rheumatol | volume = 29 | issue = 5 | pages = 938-44 | month = May | year = 2002 | doi = | PMID = 12022353 }}</ref> | |||
{| class="wikitable sortable" | |||
! Criteria | |||
! Details | |||
! Type | |||
|- | |||
| Oral symptoms | |||
| any: (1) dry mouth > 3 months, (2) require fluids for swallowing, (3) swollen salivary glands | |||
| history | |||
|- | |||
| Oral signs | |||
| any: (1) low salivary flow, (2) salivary scintigraphy positive (3) sialography positive | |||
| clinical test | |||
|- | |||
| Ocular symptoms | |||
| any: (1) dry eye > 3 months, (2) need artifical tears >3x/day, (3) foreign body sensation | |||
| history | |||
|- | |||
| Ocular signs | |||
| any: (1) Schirmer's test positive, (2) vital dye staining, (3) fluorescein tear breakup abn. | |||
| clinical test | |||
|- | |||
| Autoantibodies | |||
| any: (1) anti-SSA/Ro or anti-SSB/La, (2) ANA or RF (with other causes excluded) | |||
| serology | |||
|- | |||
| Histology | |||
| labial minor salivary gland biopsy focus score > 1.0/mm*mm | |||
| pathology | |||
|} | |||
==Microscopic== | ==Microscopic== | ||