Difference between revisions of "Medical kidney diseases"

Medical kidney diseases (view source)

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 ===Light chain deposition===
 *Usually associated with kappa clone.
+==Fibrillary glomerulonephritis==
+*[[AKA]] ''Fibrillary glomerulopathy''.
+===General===
+*Rare ~ 1% native kidney biopsies.<ref name=pmid18045849>{{Cite journal  | last1 = Alpers | first1 = CE. | last2 = Kowalewska | first2 = J. | title = Fibrillary glomerulonephritis and immunotactoid glomerulopathy. | journal = J Am Soc Nephrol | volume = 19 | issue = 1 | pages = 34-7 | month = Jan | year = 2008 | doi = 10.1681/ASN.2007070757 | PMID = 18045849 | URL = http://jasn.asnjournals.org/content/19/1/34.long }}
+</ref>
+*Presents as [[nephrotic syndrome]].
+*Prognosis poor; large number progress to ESRD.
+===Microscopic===
+Features:
+*Mesangial matrix expansion.
+*Thickened capillary walls.
+Images:
+*[http://jasn.asnjournals.org/content/19/1/34/F1.expansion.html FG (asnjournals.org)].<ref name=pmid18045849/>
+===IF===
+*IgG predominant.<ref name=pmid18045849/>
+===Stains===
+*[[Congo red stain]] -ve.
+===EM===
+*Fibrils:<ref name=pmid18045849/>
+**Non-branching.
+**Randomly arranged.
+**Usu. 18-20 nm in diameter -- larger than amyloid (see below).
+***Size range 12-24 nm.
+Note:
+*Amyloid: between 8 and 15 nm, most often 8-12 nm.<ref name=pmid18045849/>
 ==Aristolochic acid nephropathy==