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Difference between revisions of "Bullous diseases"
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→See also: +pemphigoid gestationis
(→See also: +pemphigoid gestationis) |
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*[http://www.dermpedia.org/case/acute-generalized-exanthematous-pustulosis AGEP (dermpedia.org)]. | *[http://www.dermpedia.org/case/acute-generalized-exanthematous-pustulosis AGEP (dermpedia.org)]. | ||
==Pemphigoid gestationis== | |||
*[[AKA]] ''gestational pemphigoid''. | |||
*Previously ''herpes gestationis''. | |||
===General=== | |||
*Autoimmune condition in pregnancy. | |||
**Autoantibodies against XVII collagen.<ref name=pmid21605810>{{Cite journal | last1 = Intong | first1 = LR. | last2 = Murrell | first2 = DF. | title = Pemphigoid gestationis: pathogenesis and clinical features. | journal = Dermatol Clin | volume = 29 | issue = 3 | pages = 447-52, ix | month = Jul | year = 2011 | doi = 10.1016/j.det.2011.03.002 | PMID = 21605810 }}</ref> | |||
**Fetus affected in ~5-10% of cases.<ref name=pmid17263216>{{Cite journal | last1 = Tunzi | first1 = M. | last2 = Gray | first2 = GR. | title = Common skin conditions during pregnancy. | journal = Am Fam Physician | volume = 75 | issue = 2 | pages = 211-8 | month = Jan | year = 2007 | doi = | PMID = 17263216 | URL = http://www.aafp.org/afp/2007/0115/p211.html }}</ref> | |||
*Rare - est. 1/50,000 pregnancies.<ref name=pmid18506459>{{Cite journal | last1 = Bedocs | first1 = PM. | last2 = Kumar | first2 = V. | last3 = Mahon | first3 = MJ. | title = Pemphigoid gestationis: a rare case and review. | journal = Arch Gynecol Obstet | volume = 279 | issue = 2 | pages = 235-8 | month = Feb | year = 2009 | doi = 10.1007/s00404-008-0687-3 | PMID = 18506459 }}</ref> | |||
Treatment: | |||
*Corticosteroids.<ref name=pmid21877502/> | |||
===Microscopic=== | |||
Features: | |||
*Subepidermal bullous disease.<ref>{{Cite journal | last1 = Kolanko | first1 = E. | last2 = Bickle | first2 = K. | last3 = Keehn | first3 = C. | last4 = Glass | first4 = LF. | title = Subepidermal blistering disorders: a clinical and histopathologic review. | journal = Semin Cutan Med Surg | volume = 23 | issue = 1 | pages = 10-8 | month = Mar | year = 2004 | doi = | PMID = 15095911 }}</ref> | |||
*Eosinophil - abundant. | |||
Images: | |||
*[http://commons.wikimedia.org/wiki/File:Pemphigoid_gestationis_-_low_mag.jpg PG - low mag. (WC)]. | |||
*[http://commons.wikimedia.org/wiki/File:Pemphigoid_gestationis_-_high_mag.jpg PG - high mag. (WC)]. | |||
*[http://commons.wikimedia.org/wiki/File:Pemphigoid_gestationis_-_very_high_mag.jpg PG - very high mag. (WC)]. | |||
===IF=== | |||
*C3 linear pattern at DE junction - diagnostic.<ref name=pmid21877502>{{Cite journal | last1 = Campbell | first1 = SM. | last2 = Balazs | first2 = K. | last3 = Conroy | first3 = M. | title = Pemphigoid gestationis: a case report and review of the literature. | journal = Cutis | volume = 88 | issue = 1 | pages = 21-6 | month = Jul | year = 2011 | doi = | PMID = 21877502 }}</ref> | |||
=See also= | =See also= | ||