Pulmonary neuroendocrine cell hyperplasia
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Pulmonary neuroendocrine cell hyperplasia is a proliferation of neuroendocrine cells confined by the bronchial basement membrane.
| Pulmonary neuroendocrine cell hyperplasia | |
|---|---|
| Diagnosis in short | |
|
| |
| LM | proliferation of neuroendocrine cells confined by the basement membrane of the bronchus. |
| LM DDx | carcinoid tumourlet, diffuse idiopathic pulmonary neuroendocrine cell hyperplasia, pulmonary meningothelial-like nodule |
| Site | lung |
|
| |
| Syndromes | if diffuse diffuse idiopathic pulmonary neuroendocrine cell hyperplasia (DIPNECH) |
|
| |
| Symptoms | none |
| Prevalence | very common |
| Prognosis | benign |
| Treatment | none required |
General
- Common.
- May be seen in the context of diffuse idiopathic pulmonary neuroendocrine cell hyperplasia.
Microscopic
Features:
- Proliferation of neuroendocrine cells - superficial to the basement membrane of the bronchus.[1][2]
- Salt and pepper chromatin.
Note:
- They often project into the airway.
DDx:
- Carcinoid tumourlet - extends beyond the basement membrane and less than 5 mm in maximal dimension.
- Diffuse idiopathic pulmonary neuroendocrine cell hyperplasia.
- Pulmonary meningothelial-like nodule.
See also
References
- ↑ Koo, CW.; Baliff, JP.; Torigian, DA.; Litzky, LA.; Gefter, WB.; Akers, SR. (Sep 2010). "Spectrum of pulmonary neuroendocrine cell proliferation: diffuse idiopathic pulmonary neuroendocrine cell hyperplasia, tumorlet, and carcinoids.". AJR Am J Roentgenol 195 (3): 661-8. doi:10.2214/AJR.09.3811. PMID 20729444.
- ↑ Davies, SJ.; Gosney, JR.; Hansell, DM.; Wells, AU.; du Bois, RM.; Burke, MM.; Sheppard, MN.; Nicholson, AG. (Mar 2007). "Diffuse idiopathic pulmonary neuroendocrine cell hyperplasia: an under-recognised spectrum of disease.". Thorax 62 (3): 248-52. doi:10.1136/thx.2006.063065. PMID 17099078.