Progressive transformation of germinal centers
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Progressive transformation of germinal centers, abbreviated PTGC, is a rare lymph node pathology.
| Progressive transformation of germinal centers | |
|---|---|
| Diagnosis in short | |
 PTGC. H&E stain. | |
|
| |
| LM | follicular hyperplasia with focally large germinal centers with a poorly demarcated germinal center (GC)/mantle zone interfaces (as GCs infiltrated by mantle zone lymphocytes), expanded mantle zone |
| LM DDx | nodular lymphocyte predominant Hodgkin lymphoma, other lymphomas |
| Site | lymph node |
|
| |
| Signs | lymphadenopathy |
| Symptoms | asymptomatic |
| Prevalence | very rare |
| Clin. DDx | lymph node metastasis, lymphoma |
General
- Benign.
- Classically in younger patients.
- Associated with nodular lymphocyte predominant Hodgkin lymphoma (NLPHL); NLPHL found in up to 5% in a 7 year follow-up.[1]
Clinical:
- Asymptomatic lymphadenopathy.
Microscopic
Features:
- Follicular hyperplasia (many follicles).
- Focally large germinal centers with:
- Poorly demarcated germinal center (GC)/mantle zone interfaces (as GCs infiltrated by mantle zone lymphocytes) -- key feature.[1]
- Expanded mantle zone.
Images
PTGCs - low mag. (WC)
PTGCs - intermed. mag. (WC)
PTGCs - very low mag. (WC)
PTGCs - low mag. (WC)
PTGCs - intermed. mag. (WC)
See also
References
Additional reading
- Hansmann ML, Fellbaum C, Hui PK, Moubayed P (February 1990). "Progressive transformation of germinal centers with and without association to Hodgkin's disease". Am. J. Clin. Pathol. 93 (2): 219–26. PMID 2405631.
- Kojima M, Nakamura S, Motoori T, et al. (April 2003). "Progressive transformation of germinal centers: a clinicopathological study of 42 Japanese patients". Int. J. Surg. Pathol. 11 (2): 101–7. PMID 12754626.