Pit1
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POU domain, class 1, transcription factor 1 (growth hormone factor 1), also known as POU1F1, abbreviated Pit1, is a immunostain used endocrinology.
| Pit1 | |
|---|---|
| Immunostain in short | |
| Abbreviation | Pit1 |
| Normal staining pattern | nuclear staining |
| Positive | Somatotroph, lactotroph adenoma |
General
- Nuclear stain.
Positive
Pit-1 lineage pituitary tumors:[1]
- Somatotroph adenoma.
- Lactotroph adenoma.
- Thyreotropha adenoma.
- Mammary gland.[2]
Occasionally positive
Negative
- Corticotroph adenoma.
- Gonadotroph adenoma.
- Null cell adenoma.
See also
Wikipedia page: [1]
References
- ↑ Lloyd, RV.; Osamura, RY. (Oct 1997). "Transcription factors in normal and neoplastic pituitary tissues.". Microsc Res Tech 39 (2): 168-81. doi:10.1002/(SICI)1097-0029(19971015)39:2<168::AID-JEMT8>3.0.CO;2-H. PMID 9361268.
- ↑ Sendon-Lago, J.; Seoane, S.; Eiro, N.; Bermudez, MA.; Macia, M.; Garcia-Caballero, T.; Vizoso, FJ.; Perez-Fernandez, R. (Dec 2014). "Cancer progression by breast tumors with Pit-1-overexpression is blocked by inhibition of metalloproteinase (MMP)-13.". Breast Cancer Res 16 (6): 505. doi:10.1186/s13058-014-0505-8. PMID 25527274.