Glypican 3
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Glypican 3, abbreviated GPC3,[1] is a common immunostain used in gastrointestinal pathology and genitourinary pathology.
Positive
- Hepatocellular carcinoma.[2]
- Malignant melanoma.[2]
- Squamous cell carcinoma of the lung.[2]
- Uncommon in adenocarcinoma of the lung ~3% of cases.[3]
- Yolk sac tumour.
- More sensitive than alpha-fetoprotein (AFP).[4]
Images
Positive or negative
See also
References
- ↑ Online 'Mendelian Inheritance in Man' (OMIM) 300037
- ↑ 2.0 2.1 2.2 2.3 Aydin, O.; Yildiz, L.; Baris, S.; Dundar, C.; Karagoz, F. (2015). "Expression of Glypican 3 in low and high grade urothelial carcinomas.". Diagn Pathol 10: 34. doi:10.1186/s13000-015-0266-4. PMID 25896897.
- ↑ Yu, X.; Li, Y.; Chen, SW.; Shi, Y.; Xu, F. (Aug 2015). "Differential expression of glypican-3 (GPC3) in lung squamous cell carcinoma and lung adenocarcinoma and its clinical significance.". Genet Mol Res 14 (3): 10185-92. doi:10.4238/2015.August.28.2. PMID 26345955.
- ↑ Emerson, RE.; Ulbright, TM. (Jun 2010). "Intratubular germ cell neoplasia of the testis and its associated cancers: the use of novel biomarkers.". Pathology 42 (4): 344-55. doi:10.3109/00313021003767355. PMID 20438407.