Cushing syndrome

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Cushing syndrome, also hypercortisolism, is when there is too much glucocorticoids.

Clinical

The features can be remembered with CUSHING:[1]

  • Central obesity + Cervical fat pad + Comedones (acne).
  • Unusual brUising.
  • Striae.
  • Hypertension + Hyperglycemia.
  • Immunosuppression.
  • Neoplasia may cause it.
  • Growth retardation.

A shorter version is CUSH:

  • Central obesity with peripheral wasting, Cervical fat pad.
  • Unusual brUising.
  • Straiae on Skin.
  • Hypertension + Hyperglycemia.

Microscopic

Features - pituitary gland:

  • Crooke-hyaline change:[2]
    • ACTH producing cell: basophilic granular cytoplasm becomes pale and homogenous.

  • Crooke´s cell adenoma showing various Crooke cells with hyalinzed cytoplasms. (WC/marvin101)

  • Ringlike perinuclear expression of cytokeratins in Crooke´s cell adenoma. (WC/marvin101)

See also

References

  1. ↑ URL: http://www.usmletomd.com/smartmd/2007/09/remembering-clinical-features-of.html. Accessed on: 1 May 2012.
  2. ↑ Mitchell, Richard; Kumar, Vinay; Fausto, Nelson; Abbas, Abul K.; Aster, Jon (2011). Pocket Companion to Robbins & Cotran Pathologic Basis of Disease (8th ed.). Elsevier Saunders. pp. 581. ISBN 978-1416054542.
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