Progressive transformation of germinal centers
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Progressive transformation of germinal centers, abbreviated PTGC, is a rare lymph node pathology.
Progressive transformation of germinal centers | |
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Diagnosis in short | |
PTGC. H&E stain. | |
| |
LM | follicular hyperplasia with focally large germinal centers with a poorly demarcated germinal center (GC)/mantle zone interfaces (as GCs infiltrated by mantle zone lymphocytes), expanded mantle zone |
LM DDx | nodular lymphocyte predominant Hodgkin lymphoma, other lymphomas |
Site | lymph node |
| |
Signs | lymphadenopathy |
Symptoms | asymptomatic |
Prevalence | very rare |
Clin. DDx | lymph node metastasis, lymphoma |
General
- Benign.
- Classically in younger patients.
- Associated with nodular lymphocyte predominant Hodgkin lymphoma (NLPHL); NLPHL found in up to 5% in a 7 year follow-up.[1]
Clinical:
- Asymptomatic lymphadenopathy.
Microscopic
Features:
- Follicular hyperplasia (many follicles).
- Focally large germinal centers with:
- Poorly demarcated germinal center (GC)/mantle zone interfaces (as GCs infiltrated by mantle zone lymphocytes) -- key feature.[1]
- Expanded mantle zone.
Images
See also
References
Additional reading
- Hansmann ML, Fellbaum C, Hui PK, Moubayed P (February 1990). "Progressive transformation of germinal centers with and without association to Hodgkin's disease". Am. J. Clin. Pathol. 93 (2): 219–26. PMID 2405631.
- Kojima M, Nakamura S, Motoori T, et al. (April 2003). "Progressive transformation of germinal centers: a clinicopathological study of 42 Japanese patients". Int. J. Surg. Pathol. 11 (2): 101–7. PMID 12754626.