Nodal nevus
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Nodal nevus, also capsular nevus, is benign lymph node finding that can be mistaken for malignant melanoma.[1]
| Nodal nevus | |
|---|---|
| Diagnosis in short | |
 | |
|
| |
| Synonyms | capsular nevus, benign nevus cells in lymph node |
|
| |
| LM | bland nevus cells (lack prominent nucleoli, nuclear pleomorphism, proliferative activity) |
| LM DDx | malignant melanoma |
| IHC | S-100 +ve |
| Gross | usually not apparent |
| Site | lymph node |
|
| |
| Signs | none |
| Prevalence | rare |
| Prognosis | benign |
| Clin. DDx | lymph node metastasis |
| Treatment | none or follow-up |
Nevus in lymph node and benign nevus cells in lymph node redirect here.
General
- Lymph node metastases from cutaneous melanoma are common and seen in approximately 20% of cases.[2]
- Nodal nevus may be confused with malignant melanoma.[3]
Gross
- Usually not apparent.
Microscopic
Features:
- Nevus cells with bland cytomorphology.
- Lack size variation, nucleoli.
- Non-proliferative.
Note:
- No standardized criteria.[3]
DDx:
Images
NN - very low mag. (WC)
NN - low mag. (WC)
NN - intermed. mag. (WC)
NN - high mag. (WC)
NN - very high mag. (WC)
IHC
Features:[3]
- S-100 +ve.
References
- ↑ Lee, JJ.; Granter, SR.; Laga, AC.; Saavedra, AP.; Zhan, Q.; Guo, W.; Xu, S.; Murphy, GF. et al. (Feb 2015). "5-Hydroxymethylcytosine expression in metastatic melanoma versus nodal nevus in sentinel lymph node biopsies.". Mod Pathol 28 (2): 218-29. doi:10.1038/modpathol.2014.99. PMID 25081754.
- ↑ Prieto, VG. (09 2017). "Sentinel Lymph Nodes in Cutaneous Melanoma.". Clin Lab Med 37 (3): 417-430. doi:10.1016/j.cll.2017.05.002. PMID 28802493.
- ↑ 3.0 3.1 3.2 Davis, J.; Patil, J.; Aydin, N.; Mishra, A.; Misra, S. (2016). "Capsular nevus versus metastatic malignant melanoma - a diagnostic dilemma.". Int J Surg Case Rep 29: 20-24. doi:10.1016/j.ijscr.2016.10.040. PMID 27810606.