Ovarian microcystic stromal tumour
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Ovarian microcystic stromal tumour (abbreviated MST), also microcystic stromal tumour of the ovary, is a rare ovarian tumour.
| Ovarian microcystic stromal tumour | |
|---|---|
| Diagnosis in short | |
 Microcystic stromal tumour of ovary. H&E stain. | |
|
| |
| LM | microscopic cysts alternating with solid cellular regions, hyalinized fibrous stroma |
| LM DDx | other sex cord stromal tumours |
| IHC | CD10 +ve (cytoplasmic), beta-catenin (nuclear) +ve, WT-1 +ve, cyclin D1 +ve, inhibin -ve, calretinin -ve, ER-, PR- |
| Site | ovary, testis |
|
| |
| Prevalence | rare, evolving entity |
| Prognosis | unknown |
| Clin. DDx | other ovarian tumours, testicular tumours |
| Treatment | excision |
General
- Evolving entity.
- Reported in the testis.[1]
- Likely sex cord stromal tumour.[2]
Microscopic
Features:[3]
- Microcysts alternating with solid cellular regions.
- Hyalinized fibrous stroma.
DDx:
- Other sex cord stromal tumours.
Images
MST - extremely low mag. (WC)
MST - very low mag. (WC)
MST - low mag. (WC)
MST - intermed. mag. (WC)
MST - high mag. (WC)
MST - high mag. (WC)
MST - very high mag. (WC)
IHC
Features:[3]
- CD10 +ve (cytoplasmic).
- Beta-catenin +ve (nuclear).
- WT1 +ve.
- Cyclin D1 +ve.
- Inhibin -ve.
- Calretinin -ve.
- ER -ve.
- PR -ve.
Molecular
- CTNNB1 mutation.[4]
References
- ↑ Zhu, P.; Duan, Y.; Ao, Q.; Wang, G. (Oct 2018). "Microcystic Stromal Tumor of Testicle: First Case Report and Literature Review.". Cancer Res Treat 50 (4): 1452-1457. doi:10.4143/crt.2017.414. PMID 29169232.
- ↑ Irving, JA.; Lee, CH.; Yip, S.; Oliva, E.; McCluggage, WG.; Young, RH. (Oct 2015). "Microcystic Stromal Tumor: A Distinctive Ovarian Sex Cord-Stromal Neoplasm Characterized by FOXL2, SF-1, WT-1, Cyclin D1, and β-catenin Nuclear Expression and CTNNB1 Mutations.". Am J Surg Pathol 39 (10): 1420-6. doi:10.1097/PAS.0000000000000482. PMID 26200099.
- ↑ 3.0 3.1 McCluggage, WG.; Chong, AS.; Attygalle, AD.; Clarke, BA.; Chapman, W.; Rivera, B.; Foulkes, WD. (Feb 2019). "Expanding the morphological spectrum of ovarian microcystic stromal tumour.". Histopathology 74 (3): 443-451. doi:10.1111/his.13755. PMID 30325056.
- ↑ Na, K.; Kim, EK.; Jang, W.; Kim, HS. (Jun 2017). "CTNNB1 Mutations in Ovarian Microcystic Stromal Tumors: Identification of a Novel Deletion Mutation and the Use of Pyrosequencing to Identify Reported Point Mutation.". Anticancer Res 37 (6): 3249-3258. doi:10.21873/anticanres.11688. PMID 28551672.