TDP-43
TAR-DNA-binding Protein 43, abbreviated TDP-43 is a neuropathology immunostain used in neurodegenerative diseases.
- Nuclear staining.
| TDP-43 | |
|---|---|
| Immunostain in short | |
 TDP-43 staining in FTLD-TDP43. (WC) | |
| Normal staining pattern | nuclear staining (physiological) |
| Positive | cytoplasmatic staining (pathological) |
Inclusion morphology
- fine / coarse skeins.
- dot-like.
- dense-round inclusions.
Inclusions found
- FTLD TDP-43
- Alzheimer disease.[1]
- Chronic traumatic encephalopathy (CTE).[2]
- In 30% of non-demented individuals 65yrs and older.[3]
Images
See also
References
- ↑ Wilson, AC.; Dugger, BN.; Dickson, DW.; Wang, DS. (Jan 2011). "TDP-43 in aging and Alzheimer's disease - a review.". Int J Clin Exp Pathol 4 (2): 147-55. PMID 21326809.
- ↑ McKee, AC.; Cairns, NJ.; Dickson, DW.; Folkerth, RD.; Keene, CD.; Litvan, I.; Perl, DP.; Stein, TD. et al. (Jan 2016). "The first NINDS/NIBIB consensus meeting to define neuropathological criteria for the diagnosis of chronic traumatic encephalopathy.". Acta Neuropathol 131 (1): 75-86. doi:10.1007/s00401-015-1515-z. PMID 26667418.
- ↑ Wilson, AC.; Dugger, BN.; Dickson, DW.; Wang, DS. (Jan 2011). "TDP-43 in aging and Alzheimer's disease - a review.". Int J Clin Exp Pathol 4 (2): 147-55. PMID 21326809.