Canalicular adenoma

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Canalicular adenoma is a rare salivary gland tumour.

Canalicular adenoma
Diagnosis in short

LM

cords of tumour ("canals") with beading (characteristic), cystic spaces/tubules,

intraluminal squamous balls (common)
Site salivary gland - usually upper lip

Signs mass lesion
Prevalence very rare

General

  • Exclusively oral cavity.

Clinical:

  • Mass lesion.[1]

Gross

  • Classically upper lip - may be buccal mucosa or palate.

Note:

  • In one large series of 67 cases:[1]
    • Upper lip 69% (47/67).
    • Buccal mucosa 25% (17/67).
    • Palate 6% (4/67).

Microscopic

Features:[1]

  • Cords of tumour ("canals") with beading - characteristic.
  • Cystic spaces/tubules.
  • Intraluminal squamous balls - common (~60% of cases).

DDx:

Images

IHC

  • p63 -ve.
    • Basal cell adenoma p63 +ve.

See also

References

  1. 1.0 1.1 1.2 Thompson, LD.; Bauer, JL.; Chiosea, S.; McHugh, JB.; Seethala, RR.; Miettinen, M.; Müller, S. (Jun 2015). "Canalicular adenoma: a clinicopathologic and immunohistochemical analysis of 67 cases with a review of the literature.". Head Neck Pathol 9 (2): 181-95. doi:10.1007/s12105-014-0560-6. PMID 25141970.