Talk:Low-grade squamous intraepithelial lesion

LSIL criteria

The London (cytology) criteria - 2 of 3:

1. Perinuclear clearing.
2. Membrane irregularities (5 cells in one field - FD ~ 1.1 mm).
3. Nuclear enlargement > 2x lymphocyte.

Augmented (London) criterium includes:

• Neoplastic transisition (sharp transisition from normal to abnormal - gradient over 2-3 cell distance).

Required if #3 not obvious:

• Binucleation (>2 cells).

Relative exclusions:

• Nucleoli ( >5 in one field - FD ~ 1.1 mm).

Exclusions:

• Cytoplasm to nucleus ratio =< 2:1; HSIL or invasive SCC.