Thyroid transcription factor-1
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Thyroid transcription factor-1, abbreviated TTF-1 is a transcription factor seen in lung and thyroid.[1]
| Thyroid transcription factor-1 | |
|---|---|
| Immunostain in short | |
 TTF-1 staining in lung adenocarcinoma. (WC) | |
| Normal staining pattern | nuclear staining |
| Positive | adenocarcinoma of the lung, small cell carcinoma of the lung, thyroid, hepatocellular carcinoma (cytoplasmic staining) |
| Negative | squamous cell carcinoma of the lung |
Positive staining
- Nuclear staining.
Normal tissues
Tumours
Positive staining
- Lung adenocarcinoma.[2]
- Thyroid carcinoma.
- Hepatocellular carcinoma (cytoplasmic staining).
Negative staining
See also
References
- ↑ Ordóñez, NG. (Mar 2000). "Thyroid transcription factor-1 is a marker of lung and thyroid carcinomas.". Adv Anat Pathol 7 (2): 123-7. PMID 10721419.
- ↑ Yatabe, Y.; Mitsudomi, T.; Takahashi, T. (Jun 2002). "TTF-1 expression in pulmonary adenocarcinomas.". Am J Surg Pathol 26 (6): 767-73. PMID 12023581.