Sarcomatoid urothelial carcinoma
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Sarcomatoid urothelial carcinoma (abbreviated sarcomatoid UC), also sarcomatoid urothelial cell carcinoma (abbreviated sarcomatoid UCC), is a rare variant of urothelial carcinoma.[1]
| Sarcomatoid urothelial carcinoma | |
|---|---|
| Diagnosis in short | |
 Sarcomatoid urothelial carcinoma. H&E stain. | |
| Subtypes | (subtype of urothelial carcinoma) |
| LM DDx | sarcoma, carcinosarcoma - esp. in women, other sarcomatoid carcinomas |
| Site | urothelium - urinary bladder, ureter, renal pelvis |
|
| |
| Prevalence | very rare |
| Prognosis | poor |
| Treatment | resection if feasible |
General
Gross
Microscopic
Features:
- Urothelial carcinoma (classic or recognizable variant).
- Sarcomatoid differentiation - typically (undifferentiated) spindle cells.
- Approximately have 10% of heterologous elements,[1] e.g. chondrosarcomatous differentiation, osteosarcomatous differentiation.
DDx:
- Sarcoma - esp. those arising from the retroperitoneum.
Images
Sarcomatoid UCC - low mag.
Sarcomatoid UCC - intermed. mag.
Sarcomatoid UCC - high mag.
See also
References
- ↑ 1.0 1.1 1.2 1.3 Fatima, N.; Canter, DJ.; Carthon, BC.; Kucuk, O.; Master, VA.; Nieh, PT.; Ogan, K.; Osunkoya, AO. (Jun 2015). "Sarcomatoid urothelial carcinoma of the bladder: a contemporary clinicopathologic analysis of 37 cases.". Can J Urol 22 (3): 7783-7. PMID 26068625.
- ↑ Nicolas, MM.; Nazarullah, A.; Guo, CC. (Apr 2014). "Sarcomatoid urothelial carcinoma with chondrosarcomatous differentiation of the ureter: a case report.". Anal Quant Cytopathol Histpathol 36 (2): 111-6. PMID 24902363.
- ↑ Tian, X.; Zhao, J.; Wang, Y.; Xing, N. (Sep 2014). "Sarcomatoid carcinoma of the renal pelvis: A case report.". Oncol Lett 8 (3): 1208-1210. doi:10.3892/ol.2014.2240. PMID 25120689.