Glycogenic acanthosis of the esophagus

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Glycogenic acanthosis of the esophagus is an uncommon benign change of the esophagus with a distinctive endoscopic appearance.

Glycogenic acanthosis of the esophagus
Diagnosis in short

Glycogenic acanthosis of the esophagus. H&E stain.
LM squamous epithelium with (1) superficial clearing of the cytoplasm, and (2) thickening
Site esophagus
Associated Dx gastroesophageal reflux disease (???)
Clinical history ingestion of hot liquids (???)
Prevalence uncommon
Endoscopy raised grey/white lesions
Prognosis benign

General

  • Uncommon - seen 3.5% of consecutive 2328 upper endoscopies.[1]
  • Benign.[2]
  • May be associated with GERD;[1][3] however, lesions do not resolve with PPI treatment.[2]
  • Possible association with ingestion of hot liquids.[4]
  • Described in the context of Cowden's disease when seen diffusely.[5]

Gross/endoscopic

  • Distinctive endoscopic appearance - grey/white raised lesion.[4]

Image

Microscopic

Features:[4]

  • Squamous epithelium with:
    • Superficial clearing of the cytoplasm.
    • Thickening.

Images

  • GAE - low mag.

  • GAE - intermed. mag.

  • GAE - intermed. mag.

  • GAE - high mag.

  • GAE - intermed. mag.

  • GAE - high mag.

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See also

References

  1. ↑ 1.0 1.1 Vadva, MD.; Triadafilopoulos, G. (Jul 1993). "Glycogenic acanthosis of the esophagus and gastroesophageal reflux.". J Clin Gastroenterol 17 (1): 79-83. PMID 8409304.
  2. ↑ 2.0 2.1 2.2 Tsai, SJ.; Lin, CC.; Chang, CW.; Hung, CY.; Shieh, TY.; Wang, HY.; Shih, SC.; Chen, MJ. (Jan 2015). "Benign esophageal lesions: endoscopic and pathologic features.". World J Gastroenterol 21 (4): 1091-8. doi:10.3748/wjg.v21.i4.1091. PMID 25632181.
  3. ↑ Nazligül, Y.; Aslan, M.; Esen, R.; Yeniova, AÖ.; Kefeli, A.; Küçükazman, M.; Dülger, AC.; Celik, Y. (Jun 2012). "Benign glycogenic acanthosis lesions of the esophagus.". Turk J Gastroenterol 23 (3): 199-202. PMID 22798107.
  4. ↑ 4.0 4.1 4.2 Lopes, S.; Figueiredo, P.; Amaro, P.; Freire, P.; Alves, S.; Cipriano, MA.; Gouveia, H.; Sofia, C. et al. (May 2010). "Glycogenic acanthosis of the esophagus: an unusually endoscopic appearance.". Rev Esp Enferm Dig 102 (5): 341-2. PMID 20524767.
  5. ↑ Kay, PS.; Soetikno, RM.; Mindelzun, R.; Young, HS. (Jun 1997). "Diffuse esophageal glycogenic acanthosis: an endoscopic marker of Cowden's disease.". Am J Gastroenterol 92 (6): 1038-40. PMID 9177527.
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