Medullary breast carcinoma
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Medullary breast carcinoma is an uncommon form of invasive breast carcinoma.
| Medullary breast carcinoma | |
|---|---|
| Diagnosis in short | |
|
| |
| LM | all required: (1) lesion has well-circumscribed border, (2) syncytial growth pattern, (3) lymphocytic infiltrate, (4) high nuclear grade (as per Nottingham grading system), (5) no tubule formation |
| LM DDx | Invasive ductal carcinoma with medullary features |
| IHC | ER -ve, PR -ve, HER2 -ve |
| Site | breast - see invasive breast cancer |
|
| |
| Prevalence | uncommon |
| Prognosis | better than NST |
It is also known as medullary carcinoma of the breast.
General
- Uncommon breast cancer subtype.
- Some pathologists very rarely make the diagnosis.[citation needed]
Epidemiology:
- Thought to have a better prognosis that no special type (NST).
- May be associated with a BRCA1 mutation.
Gross
- Well-circumscribed border.[1]
Aside - malignant well-circumscribed breast masses - radiologic DDx:[1]
- Medullary breast carcinoma.
- Mucinous breast carcinoma.
- Malignant phyllodes tumour.
- Invasive papillary carcinoma of the breast.
Microscopic
Features:
- Lesion has well-circumscribed border.
- Syncytial growth pattern = clumps of cells with poorly defined cell borders.
- Lymphocytic infiltrate.
- High nuclear grade (as per Nottingham grading system).
- No tubule formation.
DDx:
- Invasive ductal carcinoma with medullary features.
Images
Breast - Medullary Carcinoma - low power (SKB)
Breast - Medullary Carcinoma - medium power (SKB)
Breast - Medullary Carcinoma - high power (SKB)
_PA.JPG)
IHC
Features - typical:[2]
- ER -ve.
- PR -ve.
- HER2 -ve.
See also
References
- ↑ 1.0 1.1 Yoo, JL.; Woo, OH.; Kim, YK.; Cho, KR.; Yong, HS.; Seo, BK.; Kim, A.; Kang, EY. (Oct 2010). "Can MR Imaging contribute in characterizing well-circumscribed breast carcinomas?". Radiographics 30 (6): 1689-702. doi:10.1148/rg.306105511. PMID 21071383.
- ↑ Matkovic, B.; Juretic, A.; Separovic, V.; Novosel, I.; Separovic, R.; Gamulin, M.; Kruslin, B.. "Immunohistochemical analysis of ER, PR, HER-2, CK 5/6, p63 and EGFR antigen expression in medullary breast cancer.". Tumori 94 (6): 838-44. PMID 19267102.