Bizarre parosteal osteochondromatous proliferation

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Bizarre parosteal osteochondromatous proliferation, also known as Nora lesion, is a distinctive rare lesion of the hand or foot.[1]

Bizarre parosteal osteochondromatous proliferation
Diagnosis in short

Synonyms Nora lesion
Site hands, feet

Prevalence rare

General

A distinctive osteochondromatous proliferation of hands and feet.

Population:

  • Young adults.
  • Typically age (years) 20s and 30s.[1]

Location

Hands and feet

Radiology

  • Marginated wide based bony growth projecting into the soft tissues.[2]

Gross

  • Nodule covered with glistening cartilage.

Microscopic

Disorganized cellular cartilage with a blue tint and patchy ossification matures into disorganized bone. A proliferation of fibroblasts surrounds the lesion and occupies intertrabecular spaces.

DDx:

Images

  • BPOP[1]
  • BPOP - Web Pathology - radiology and histology[2]
  • BPOP[3]

Diangostic categories

  • Cartilaginous neoplasms
  • Osteocartilaginous neoplasms

Molecular

t(1:17)(q32;q21)[3]

Sign out

  • BIZARRE PAROSTEAL OSTEOCHONDROMATOUS PROLIFERATION (NORA LESION).
  • APPROPRIATE MARGIN STATEMENT.

Prognosis

  • Benign
  • Locally aggressive

See also

  • Pathology Outlines[4]

References

  1. 1.0 1.1 Gruber, G.; Giessauf, C.; Leithner, A.; Zacherl, M.; Clar, H.; Bodo, K.; Windhager, R. (Dec 2008). "Bizarre parosteal osteochondromatous proliferation (Nora lesion): a report of 3 cases and a review of the literature.". Can J Surg 51 (6): 486-9. PMID 19057740.
  2. http://radiopaedia.org/articles/bizarre-parosteal-osteochondromatous-proliferation
  3. Kuruvilla, S.; Marco, R.; Raymond, AK.; Al-Ibraheemi, A.; Tatevian, N. (2011). "BizarreParosteal Osteochondromatous Proliferation (Nora's lesion) with translocation t(1;17)(q32;q21): a case report and role of cytogenetic studies on diagnosis.". Ann Clin Lab Sci 41 (3): 285-7. PMID 22075515.