P16

p16 is a commonly used immunostain. It can be considered a surrogate marker for HPV infection. p16, like most other "p" stains, is a nuclear stain.

HSIL showing the characteristic p16 staining.

Pattern

• Nuclear stain +/- cytoplasmic staining.

Use

• Squamous lesions of the uterine cervix.
• Head and neck squamous cell carcinoma, specifically human papillomavirus-associated head and neck squamous cell carcinoma.

External links

• Interpretation of p16 (mtmlabs.com).