Pyloric gland adenoma
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Pyloric gland adenoma, abbreviated PGA, is an uncommon gastrointestinal lesion.
| Pyloric gland adenoma | |
|---|---|
| Diagnosis in short | |
|
| |
| LM | foveolar-type glands with eosinophilic (or clear) cytoplasm, nuclei with or without dysplasia |
| LM DDx | foveolar-type gastric adenoma, well-differentiated gastric adenocarcinoma |
| IHC | MUC6 +ve, MUC5AC +ve, Ki-67 high |
| Site | stomach, duodenum, gallbladder, others |
|
| |
| Associated Dx | well-differentiated gastric adenocarcinoma, autoimmune gastritis |
| Prevalence | uncommon |
| Endoscopy | polyp |
| Prognosis | benign |
| Clin. DDx | other polyps |
| Treatment | excision |
General
- Approximately 3% of gastric polyps.[1]
- Associated with autoimmune gastritis.[2]
- More often seen in women as with autoimmune gastritis.
- Associated with gastric adenocarcinoma.
Microscopic
Features:[3]
- Round mildly irregular foveolar-type glands with:
- Nuclei without dysplasia (round and basally located nuclei) or with dysplasia.
- Moderate eosinophilic (or clear) cytoplasm.
DDx:
- Gastric adenoma, foveolar-type.
- Adenocarcinoma of the stomach, well-differentiated.
IHC
See also
References
- ↑ Vieth, M.; Vogel, C.; Kushima, R.; Borchard, F.; Stolte, M. (Jan 2006). "Pyloric gland adenoma-- how to diagnose?". Cesk Patol 42 (1): 4-7. PMID 16506593.
- ↑ Vieth, M.; Montgomery, EA. (Aug 2014). "Some observations on pyloric gland adenoma: an uncommon and long ignored entity!". J Clin Pathol. doi:10.1136/jclinpath-2014-202553. PMID 25092673.
- ↑ 3.0 3.1 3.2 Chen, ZM.; Scudiere, JR.; Abraham, SC.; Montgomery, E. (Feb 2009). "Pyloric gland adenoma: an entity distinct from gastric foveolar type adenoma.". Am J Surg Pathol 33 (2): 186-93. doi:10.1097/PAS.0b013e31817d7ff4. PMID 18830123.