Emperipolesis

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Emperipolesis is an intact cell within another cell. The term is derived from em (inside), peri (around), and polemai (is wander about).

Emperipolesis in Rosai-Dorfman disease. H&E stain.

General

Nonspecific finding seen in a number of conditions.

It is seen in:

Microscopic

Features:

Intact cell (e.g. lymphocyte, neutrophil) within a macrophage.
- Engulfed cell usually has a halo around it.

DDx:

Cell overlap.
Hemophagocytosis.

Images

Emperipolesis in Rosai-Dorfman disease. S100 immunostain.
Megakaryocyte containing a neutrophil. May-Grünwald Giemsa stain.

See also

Hemophagocytic syndrome.

References

↑ Cashell AW, Buss DH (June 1992). "The frequency and significance of megakaryocytic emperipolesis in myeloproliferative and reactive states". Ann. Hematol. 64 (6): 273–6. PMID 1637881.

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