Intravascular large B-cell lymphoma
Intravascular large B-cell lymphoma refers to a rare form of lymphoma that is intravascular, B-cell derived, and does not manifest as a mass.
Several terms have been use to refer this entity, including angiotropic lymphoma, intravascular malignant lymphomatosis and malignant angioendotheliomatosis.
General
Clinical:
- Often a non-specific presentation.[1]
- +/-Fever.
- +/-Multiple infarcts.
- +/-Non-specific skin lesions.
Microscopic
Features:
- Abundant atypical intravascular lymphoid cells that are:
- Large (~2-3X size of a mature lymphocyte or RBC).
- Nucleolus prominent.
Notes:
- It may be hard to find RBCs in the vessels.
- Looks sorta like a DLBCL -- but is intravascular.
Images
Intravascular lymphoma - high mag. (WC/Nephron)
Intravascular lymphoma - very high mag. (WC/Nephron)
www:
IHC
Features:[1]
- CD20 +ve - key feature.
- CD3 -ve.
- CD34 -ve.
See also
References
- ↑ 1.0 1.1 1.2 Lapkuviene O, Forchetti D, Roepke JE (October 2001). "Unusual sites of involvement by hematologic malignancies. Case 1. Intravascular large B-cell lymphoma presenting with CNS symptoms". J. Clin. Oncol. 19 (19): 3988–91. PMID 11579120. http://jco.ascopubs.org/content/19/19/3988.full.
- ↑ URL: http://path.upmc.edu/cases/case473.html. Accessed on: 21 January 2012.