Intravascular large B-cell lymphoma

From Libre Pathology
Revision as of 04:05, 9 March 2014 by Michael (talk | contribs) (split out)
Jump to navigation Jump to search

Intravascular large B-cell lymphoma refers to a rare form of lymphoma that is intravascular, B-cell derived, and does not manifest as a mass.

Several terms have been use to refer this entity, including angiotropic lymphoma, intravascular malignant lymphomatosis and malignant angioendotheliomatosis.

General

Clinical:

  • Often a non-specific presentation.[1]
    • +/-Fever.
    • +/-Multiple infarcts.
    • +/-Non-specific skin lesions.

Microscopic

Features:

  • Abundant atypical intravascular lymphoid cells that are:
    • Large (~2-3X size of a mature lymphocyte or RBC).
    • Nucleolus prominent.

Notes:

  • It may be hard to find RBCs in the vessels.
  • Looks sorta like a DLBCL -- but is intravascular.

Images

  • Intravascular lymphoma - high mag. (WC/Nephron)

  • Intravascular lymphoma - very high mag. (WC/Nephron)

www:

IHC

Features:[1]

  • CD20 +ve - key feature.
  • CD3 -ve.
  • CD34 -ve.

See also

References

  1. ↑ 1.0 1.1 1.2 Lapkuviene O, Forchetti D, Roepke JE (October 2001). "Unusual sites of involvement by hematologic malignancies. Case 1. Intravascular large B-cell lymphoma presenting with CNS symptoms". J. Clin. Oncol. 19 (19): 3988–91. PMID 11579120. http://jco.ascopubs.org/content/19/19/3988.full.
  2. ↑ URL: http://path.upmc.edu/cases/case473.html. Accessed on: 21 January 2012.
Retrieved from "https://librepathology.org/w/index.php?title=Intravascular_large_B-cell_lymphoma&oldid=30181"