Eosinophilic gastritis
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Eosinophilic gastritis, abbreviated EG, is an uncommon inflammatory process of stomach characterized by abundant eosinophils.
| Eosinophilic gastritis | |
|---|---|
| Diagnosis in short | |
 Stomach with eosinophilia. H&E stain. | |
|
| |
| LM | abundant eosinophils (>=127 eosinophils/mm2) |
| LM DDx | chronic gastritis, Helicobacter gastritis, Crohn's disease - see inflammatory bowel disease and the stomach, eosinophilic myeloproliferative neoplasm, eosinophilic gastroenteritis |
| Site | stomach |
|
| |
| Symptoms | +/-abdominal pain |
| Prevalence | very rare |
| Prognosis | benign? |
| Clin. DDx | other causes of gastritis |
General
- Rare.
Clinical:
Gross
DDx:
Microscopic
Features:
- Abundant eosinophils -- >=127 eosinophils/mm2.[3]
- 30 eosinophils/HPF, if the field diameter of 1 HPF is 0.55 mm.
Notes:
- Normal range:[3]
- <38 eosinophils/mm2.
- Typically ~16 eosinophils/mm2.
- <38 eosinophils/mm2.
- Mild eosinophilia is seen in:[3]
- Crohn's disease ~ 31 eosinophils/mm2 (range: 0-203 eosinophils/mm2).
- Helicobacter gastritis ~ 25 eosinophils/mm2 (range: 0-219 eosinophils/mm2).
DDx:
- Chronic gastritis.
- Helicobacter gastritis.
- Crohn's disease - see inflammatory bowel disease and the stomach.
- Eosinophilic myeloproliferative neoplasm.
- Eosinophilic gastroenteritis.
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Focal eosinophilia
STOMACH, BIOPSY: - BODY AND ANTRAL-TYPE GASTRIC MUCOSA WITH MODERATE CHRONIC ACTIVE INFLAMMATION AND FOCAL EOSINOPHILIA. - NEGATIVE FOR HELICOBACTOR-LIKE ORGANISMS. - NEGATIVE FOR INTESTINAL METAPLASIA. - NEGATIVE FOR DYSPLASIA AND NEGATIVE FOR MALIGNANCY. COMMENT: One of four tissue fragments has eosinophilia, with 45 eosinophils/1 HPF (where 1 HPF is 0.2376 mm*mm).
See also
References
- ↑ Ayyub, M.; Almenawi, L.; Mogharbel, MH.. "Eosinophilic gastritis; an unusual and overlooked cause of chronic abdominal pain.". J Ayub Med Coll Abbottabad 19 (4): 127-30. PMID 18693615.
- ↑ Holroyd, DJ.; Banerjee, S.; Chaudhary, KS.; Reshamwalla, S.; Vijay, V.; Ward, MW. (May 2010). "Transmural eosinophilic gastritis with gastric outlet obstruction: case report and review of the literature.". Ann R Coll Surg Engl 92 (4): W18-20. doi:10.1308/147870810X12659688851915. PMID 20501003.
- ↑ 3.0 3.1 3.2 Lwin, T.; Melton, SD.; Genta, RM. (Apr 2011). "Eosinophilic gastritis: histopathological characterization and quantification of the normal gastric eosinophil content.". Mod Pathol 24 (4): 556-63. doi:10.1038/modpathol.2010.221. PMID 21169993.