Proton pump inhibitor effect
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Proton pump inhibitor effect, abbreviated PPI effect, is a change seen in the parietal cells of the stomach due to a drug in the proton pump inhibitor class.
Stomach with PPI effect. H&E stain.
Formally, it is stomach with proton pump inhibitor effect.
General
- Due to intake of a proton pump inhibitor (PPI).
- Used to treat gastroesophageal reflux disease.
Some proton pump inhibitors
| Generic name | Brand name(s) |
|---|---|
| Omeprazole | LOSEC |
| Dexlansoprazole | DEXILANT |
| Lansoprazole | PREVACID |
| Esomeprazole | NEXIUM |
| Pantoprazole | PANTOLOC |
| Rabeprazole | PARIET |
Microscopic
Features:[1]
- Parietal cell enlargement - key feature.
- Parietal cells typically bulge into the lumen.
Images
PPI effect - intermed. mag.
PPI effect - high mag.
PPI effect - very high mag.
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- Usually not reported.