Proton pump inhibitor effect

Proton pump inhibitor effect, abbreviated PPI effect, is a change seen in the parietal cells of the stomach due to a drug in the proton pump inhibitor class.

Stomach with PPI effect. H&E stain.

Formally, it is stomach with proton pump inhibitor effect.

General

• Due to intake of a proton pump inhibitor (PPI).
  • Used to treat gastroesophageal reflux disease.

Some proton pump inhibitors:

• Omeprazole (LOSEC).
• Dexlansoprazole (DEXILANT).
• Lansoprazole (PREVACID).
• Esomeprazole (NEXIUM).
• Pantoprazole (PANTOLOC).
• Rabeprazole (PARIET).

Microscopic

Features:

• Parietal cell enlargement - key feature.
  • Parietal cells typically bulge into the lumen.

Images

• 

  PPI effect - intermed. mag.

• 

  PPI effect - high mag.

• 

  PPI effect - very high mag.

www:

• PPI effect (nature.com).

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• Usually not reported.

See also

• Stomach.