Hyaline globules
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Hyaline globules, also hyaline bodies, are a common non-specific histomorphologic feature that can be useful in formulating a differential diagnosis.
They can be seen in benign and malignant tissue.
Microscopic
Features:
- Eosinophilic (pink) round bodies ~ typically 4-10 micrometers in diameter.
Benign
- Ectopic decidua.[1]
Tumours
Gynecologic:
- Clear cell carcinoma (CCC).
- Yolk sac tumour, hepatoid pattern.[2]
Gastrointestinal:
- Solid pseudopapillary tumour.[3]
- Pancreatic endocrine tumour.[3]
- Hepatocellular carcinoma - very common.[4]
Other:
Images
Hyaline globules in CCC - very high mag. (WC)].
References
- ↑ Dharan M (September 2009). "Hyaline globules in ectopic decidua in a pregnant woman with cervical squamous cell carcinoma". Diagn. Cytopathol. 37 (9): 696–8. doi:10.1002/dc.21113. PMID 19526574.
- ↑ URL: http://webpathology.com/image.asp?case=34&n=6. Accessed on: March 8, 2010.
- ↑ 3.0 3.1 Serra S, Chetty R (November 2008). "Revision 2: an immunohistochemical approach and evaluation of solid pseudopapillary tumour of the pancreas". J. Clin. Pathol. 61 (11): 1153–9. doi:10.1136/jcp.2008.057828. PMID 18708424. http://jcp.bmj.com/content/61/11/1153.
- ↑ 4.0 4.1 Nayar, R.; Bourtsos, E.; DeFrias, DV. (Oct 2000). "Hyaline globules in renal cell carcinoma and hepatocellular carcinoma. A clue or a diagnostic pitfall on fine-needle aspiration?". Am J Clin Pathol 114 (4): 576-82. doi:10.1309/F4TU-6AFE-R7NU-39Y3. PMID 11026104.