Serous carcinoma of the ovary

Serous carcinoma of the ovary, also ovarian serous carcinoma, is relatively common malignant ovarian tumour.

General

Features:

Marked nuclear pleomorphism:
- Variation in size - usually marked.
- Variation in staining.
- Variation in shape.
Prominent nucleolus - key feature.
Eccentric nucleus.
Architecture:
- Solid.
- Papillary - classic.
- Glandular - uncommon.
+/-Psammoma bodies - uncommon.
+/-Necrosis - often extensive.

DDx:

Clear cell carcinoma of the ovary - less nuclear size variation.
Endometrioid carcinoma of the ovary - usu. lower grade.
Primary peritoneal serous carcinoma - bulk of tumour in peritoneum, small ovarian tumour.
Other non-ovarian serous carcinomas - see serous carcinoma.
Ovarian serous borderline tumour - mild to moderate nuclear atypia, no invasion, few mitoses.

Others:

↑ Köbel, M.; Kalloger, SE.; Carrick, J.; Huntsman, D.; Asad, H.; Oliva, E.; Ewanowich, CA.; Soslow, RA. et al. (Jan 2009). "A limited panel of immunomarkers can reliably distinguish between clear cell and high-grade serous carcinoma of the ovary.". Am J Surg Pathol 33 (1): 14-21. doi:10.1097/PAS.0b013e3181788546. PMID 18830127.
↑ DeLair, D.; Oliva, E.; Köbel, M.; Macias, A.; Gilks, CB.; Soslow, RA. (Jan 2011). "Morphologic spectrum of immunohistochemically characterized clear cell carcinoma of the ovary: a study of 155 cases.". Am J Surg Pathol 35 (1): 36-44. doi:10.1097/PAS.0b013e3181ff400e. PMID 21164285.
↑ Tsuchiya, A.; Sakamoto, M.; Yasuda, J.; Chuma, M.; Ohta, T.; Ohki, M.; Yasugi, T.; Taketani, Y. et al. (Dec 2003). "Expression profiling in ovarian clear cell carcinoma: identification of hepatocyte nuclear factor-1 beta as a molecular marker and a possible molecular target for therapy of ovarian clear cell carcinoma.". Am J Pathol 163 (6): 2503-12. PMID 14633622. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1892387/?tool=pubmed.
↑ Online 'Mendelian Inheritance in Man' (OMIM) 189907