Renomedullary interstitial cell tumour

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Renomedullary interstitial cell tumour, also known as medullary fibroma,[1] is a relatively common benign tumour of the kidney.

Renomedullary interstitial cell tumour
Diagnosis in short

Renal medullary fibroma. H&E stain.
Synonyms renal medullary fibroma
LM small polygonal/stellate cells in abundant loose/myxoid stroma, +/-entrapped renal tubules
IHC alpha-SMA +ve, CD35 +ve
Gross small (usu. <3 mm), white, well-circumscribed nodule - medulla of kidney
Site kidney - see kidney tumours
Prevalence common
Prognosis benign

General

  • Benign.
  • Common autopsy finding[2] - one review says 26-41% of individuals at autopsy.[3]
    • The commonality is somewhat in dispute.[4]

Gross

  • Small, white well-circumscribed nodule in medulla.
    • Typically less than 3 mm.[3]

Image:

Microscopic

Features:[2][5]

  • Small polygonal/stellate cells.
  • Abundant loose/myxoid stroma.
  • +/-Entrapped renal tubules.[6]

Images

  • Renal medullary fibroma - low mag. (WC/Nephron)

  • Renal medullary fibroma - intermed. mag. (WC/Nephron)

  • Renal medullary fibroma - high mag. (WC/Nephron)

  • Renal medullary fibroma - very high mag. (WC/Nephron)

www:

IHC

Features:[6]

  • Alpha-smooth muscle actin +ve.
  • CD35 +ve.

See also

References

  1. ↑ Bircan, S.; Orhan, D.; Tulunay, O.; Safak, M. (2000). "Renomedullary interstitial cell tumor.". Urol Int 65 (3): 163-6. PMID 11054036.
  2. ↑ 2.0 2.1 Humphrey, Peter A; Dehner, Louis P; Pfeifer, John D (2008). The Washington Manual of Surgical Pathology (1st ed.). Lippincott Williams & Wilkins. pp. 295. ISBN 978-0781765275.
  3. ↑ 3.0 3.1 Tsurukawa, H.; Iuchi, H.; Osanai, H.; Yamaguchi, S.; Hashimoto, H.; Kaneko, S.; Yachiku, S. (Jan 2000). "[Renomedullary interstitial cell tumor: a case report].". Nihon Hinyokika Gakkai Zasshi 91 (1): 37-40. PMID 10689882.
  4. ↑ Kozłowska, J.; Okoń, K. (2008). "Renal tumors in postmortem material.". Pol J Pathol 59 (1): 21-5. PMID 18655367.
  5. ↑ URL: http://webpathology.com/image.asp?n=16&Case=71. Accessed on: 17 October 2011.
  6. ↑ 6.0 6.1 Kuroda, N.; Toi, M.; Miyazaki, E.; Hayashi, Y.; Nakayama, H.; Hiroi, M.; Enzan, H.. "Participation of alpha-smooth muscle actin-positive cells in renomedullary interstitial cell tumors.". Oncol Rep 9 (4): 745-50. PMID 12066202.
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