Gonadoblastoma

Gonadoblastoma
	Diagnosis in short
	; Gondaloblastoma. H&E stain.
LM	immature germ cells (resembling Sertoli cells or granulosa cells),[citation needed] primitive germ cells resemble those of a dysgerminoma, +/-calcification (very common), +/-eosinophilic basement membrane material between the (primitive) germ cells and support cells.
LM DDx	dysgerminoma
Site	ovary
Clinical history	abnormal sexual development
Prevalence	very rare

Gonadoblastoma is a rare germ cell tumour with sex cord elements.

General

Associated with abnormal sexual development.
Often coexist with a dysgerminoma.
A mixed tumour that consists of (1) primitive germ cells and (2) sex cord elements.

Features:^[1]

Immature germ cells resembling Sertoli cells or granulosa cells.^{[citation needed]}
- Sertoli cells = moderate cytoplasm in a trabecular or tubular architecture.
- Granulosa cells = form follicle-like structures.
  - May form nests.
Primitive germ cells resemble those of a dysgerminoma.
- Polygonal cells with a central nucleus, squared-off nuclear membrane and clear cytoplasm.
+/-Calcification (very common).
+/-Eosinophilic basement membrane material between the (primitive) germ cells and support cells.^[2]

www:

↑ Cotran, Ramzi S.; Kumar, Vinay; Fausto, Nelson; Nelso Fausto; Robbins, Stanley L.; Abbas, Abul K. (2005). Robbins and Cotran pathologic basis of disease (7th ed.). St. Louis, Mo: Elsevier Saunders. pp. 1104. ISBN 0-7216-0187-1.
↑ URL: http://www.flickr.com/photos/ckrishnan/3972432044/in/photostream/. Accessed on: 11 September 2011.

Gonadoblastoma
Diagnosis in short
Gondaloblastoma. H&E stain.

LM	immature germ cells (resembling Sertoli cells or granulosa cells),^{[citation needed]} primitive germ cells resemble those of a dysgerminoma, +/-calcification (very common), +/-eosinophilic basement membrane material between the (primitive) germ cells and support cells.
LM DDx	dysgerminoma
Site	ovary

Clinical history	abnormal sexual development
Prevalence	very rare