Sickle cell disease

Sickle cell disease, also sickle cell anemia, is a heritable haematologic disorder associated with serious pathologies.

Liver

Main article: Liver

• Cirrhosis and liver failure.

Images:

• Sickle cell disease and cirrhosis - intermed. mag. (WC).
• Sickle cell disease and cirrhosis - very high mag. (WC).

Spleen

Main article: Spleen

• It may lead to auto infarction - result in hypofunction.
  • Splenectomy have increased risk from polysaccharide encapsulated bacteria, i.e. Neisseria meningitis, Haemophilus influenzae, and Streptococcus pneumoniae.

Gallbladder

Main article: Gallbladder

• Pigment stones.

Kidney

• Renal medullary carcinoma associated with sickle cell trait (heterozygotes for the sickle cell allele).

See also

• Haematopathology.
• Red blood cell.