P40
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| P40 | |
|---|---|
| Immunostain in short | |
| Similar stains | p63 |
| Use | lung (adenocarcinoma vs. squamous) |
| Normal staining pattern | nuclear staining |
| Positive | squamous cell carcinoma, urothelial carcinoma |
| Negative | prostate carcinoma, most lung adenocarcinoma, breast carcinoma |
p40 an immunostain that is both sensitive and specific for squamous cell carcinoma.
General
- Considered superior to p63 as it is more specific.[1]
- p63 stains a significant number of adenocarcinoma.
Staining
Positive
Negative
See also
- p63.
References
- ↑ Bishop, JA.; Teruya-Feldstein, J.; Westra, WH.; Pelosi, G.; Travis, WD.; Rekhtman, N. (Mar 2012). "p40 (ΔNp63) is superior to p63 for the diagnosis of pulmonary squamous cell carcinoma.". Mod Pathol 25 (3): 405-15. doi:10.1038/modpathol.2011.173. PMID 22056955.