Fibrosing pleuritis

Fibrosing pleuritis, also fibrous pleurisy, is an uncommon benign condition that mimics malignant mesothelioma.

It may be referred to as cryptogenic bilateral fibrosing pleuritis, if it is bilateral.

General

• Benign.
• No asbestos exposure.

Clinical:

• Pleural thickening on imaging.
• Pleural effusion.

Gross

• Pleural thickening associated with a pleural effusion.

Microscopic

Features:^{[citation needed]}

• Fibrosis.
  • Spindle cells.
  • Moderate cellularity.
• No necrosis.
• Inflammation - lymphocytes.

DDx:

• Mesothelioma, desmoplastic.

IHC

• p53 -ve/+ve.
  • More common in mesothelioma.

See also

• Medical lung diseases.