Carcinosarcoma
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Carcinosarcoma is a tumour with a malignant epithelial component (carcinoma) and a malignant mesenchymal component (sarcoma), based on histomorphology.
They can arise in a number of sites:
- Uterine carcinosarcoma (most common).
- Ovarian carcinosarcoma.
- Fallopian tube carcinosarcoma.
Relation to carcinoma, metaplastic carcinoma and sarcomatoid carcinoma
Carcinosarcoma implies that the tumour arose from mesenchymal cells and epithelial cells simultaneously.
This is in contradistinction to (1) sarcomatoid carcinomas which arise from epithelial cells and then transform to become sarcoma-like, and (2) metaplastic carcinomas which arise from epithelial cells that have undergone a (morphologic) transformation (metaplasia).
Uterine carcinosarcomas are generally considered metaplastic carcinomas;[1][2] they putatively arise from epithelial cells (only).
See also
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- ↑ Cantrell, LA.; Blank, SV.; Duska, LR. (Jun 2015). "Uterine carcinosarcoma: A review of the literature.". Gynecol Oncol 137 (3): 581-588. doi:10.1016/j.ygyno.2015.03.041. PMID 25805398.
- ↑ Artioli, G.; Wabersich, J.; Ludwig, K.; Gardiman, MP.; Borgato, L.; Garbin, F. (Apr 2015). "Rare uterine cancer: carcinosarcomas. Review from histology to treatment.". Crit Rev Oncol Hematol 94 (1): 98-104. doi:10.1016/j.critrevonc.2014.10.013. PMID 25468677.